Single-nucleus transcriptomic profiling of cortical SST+ GABAergic interneurons in Alzheimer's disease to resolve selective metabolic vulnerability, modeling the pathogenic collapse of the PPARGC1A mitochondrial biogenesis regulon against SATB1-mediated cell-identity homeostasis.
differential-expression pathway-enrichment-analysis neurodegeneration gene-regulatory-networks gabaergic-neurons single-nucleus-rna-seq somatostatin-interneurons alzheimers-pathology selective-vulnerability mitochondrial-biogenesis ppargc1a-regulon satb1-chromatin transcriptional-collapse cortical-microcircuitry bioenergetic-failure snrna-seq-pipeline hypergeometric-ora regulon-activity-scoring
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Updated
Jun 25, 2026 - Python