MurineMatchTx is an R package designed to address a central challenge in translational cancer research: quantitatively evaluating the transcriptional similarity between mouse models and human cancer samples. It provides a streamlined pipeline for cross-species integration of RNA-seq data, enabling researchers to assess the fidelity of preclinical models in mimicking human tumor biology.
By integrating DEG analysis, PCA, TROM scoring, immune profiling, and GO enrichment in a unified workflow, MurineMatchTx helps researchers systematically identify which mouse models best resemble human tumor subtypes at the transcriptomic level.
You can install the package directly from GitHub:
# Install devtools if necessary
if (!require("devtools")) install.packages("devtools")
# Install the package
devtools::install_github("wangdian-PKU/MurineMatchTx")Detailed guidance of how to use MurineMatchTx could be found in the https://wangdian-pku.github.io/MurineMatchTxManual/.
We are always open to your questions and encourage discussions here.
You can report potential bugs to the issues.
Any question can directly contact the author by email: wangdian@bjmu.edu.cn