Dissecting post-mortem autolysis kinetics and miRNA-mediated post-transcriptional silencing networks in Alzheimer's parietal cortex. Isolates disease-associated signals in RISC-complexed miRNAs and unstable mRNA decay targets (SIRT1, FOXO1, ITPKB, BACE1) using a multivariable covariate-adjusted OLS framework.
systems-biology neurodegeneration gene-regulatory-networks neuroinflammation post-transcriptional-silencing risc-complex post-mortem-autolysis transcript-decay-kinetics alzheimers-pathopathology parietal-cortex-interactome synaptic-decay tau-hyperacetylation microglial-activation ship1-signaling sirt1-foxo1-axis bace1-regulation molecular-neurobiology
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Jun 24, 2026 - Python