kras

Efficient server proxying and mocking in Node.js. 💪

A single-cell transcriptomic analysis of endometriosis, endometriomas, eutopic endometrial samples and uninvolved ovary tissues highlights cell populations characteristic of these tissue types. Transcriptional and cellular heterogeneity across tissues suggests novel therapeutic targets and biomarkers for this disease.

Official repository for the OUP published paper: "Computational Design of a Predicted High-Affinity Humanised Nanobody against KRAS Switch-I". Includes the PIA-KRASv2-Nb sequence, 3D models, and validation data.

Churn_Modelling Using Deep Learning (Implemented ANN)

A genetic study of the allele- and tissue- specific interactions of the KRAS alleles.

Mock web service APIs by providing Swagger YAML files. 💪

Validated computational drug-discovery pipeline for KRAS in pancreatic ductal adenocarcinoma (PDAC). Four validated targets (G12C/G12D/G12V/G12R), 518,662 gated compounds, three virtual screens, MM-GBSA rescoring, and a self-audit of a generative campaign whose molecules could not be synthesised. All negative results released.

Please cite our paper: Bhyravbhatla N*, Alsafwani ZW*, Thapa I, et al. Targeting Oncomucin-driven Immunosuppression Improves the Efficacy of K-rasG12D Inhibition in Pancreatic Cancer. Gastroenterology. Published online May 25, 2026. doi:10.1053/j.gastro.2026.04.041

Manuscript for the KRAS comutation research project.

The default frontend / management portal for the kras server. 💪

Somatic mutations in TCGA lung adenocarcinoma — maftools workflow

LLM-driven multi-agent simulation of the KRAS G12D pancreatic tumor microenvironment — emergent immunosuppression, NK/DC agents, ablation studies. bioRxiv 2026.