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Haplo Haplo

The genomic safety layer for every prescription.

Lab-agnostic pharmacogenomic decision support for the long tail of clinics and pharmacies.
Any lab's genetic test → instant, CPIC-based prescribing guidance.

engine verified genes cpic license


In ancient Greek, pharmakon meant both remedy and poison — the same substance, two opposite fates. Which one a drug becomes is written in the patient's genes. Haplo reads that line before the script is written.

What this is

A complete, funder-ready package for Haplo, a pharmacogenomic (PGx) decision-support venture:

File What it is
index.html Marketing landing page (bio-luxe brand)
app.html Working software MVP — a real CPIC-based interpretation engine
deck.html 13-slide investor pitch deck (arrow-key navigable)
design.md Full design system — tokens, logo rules, type, voice
docs/market-research.md Market research & venture thesis, with sources
assets/ Logo set (SVG + PNG), favicon, Open Graph card

The product

The app is not a mockup. It computes a patient's drug-metabolizer phenotype from star-allele diplotypes using CPIC activity-score and allele-function logic across 12 genes, reconciles the result against a full medication list, and returns severity-ranked, guideline-cited prescribing guidance with specific alternative drugs.

Genes: CYP2C19 · CYP2D6 · CYP2C9 · VKORC1 · SLCO1B1 · TPMT · NUDT15 · DPYD · UGT1A1 · CYP3A5 · HLA-B*57:01 · HLA-B*15:02 / HLA-A*31:01 Representative drugs: clopidogrel, codeine, tramadol, tamoxifen, warfarin, simvastatin, azathioprine, capecitabine, abacavir, carbamazepine, tacrolimus, and more.

Open app.html and click a sample patient (Maria · James · Eleanor · David) to see multi-drug findings, or set any genotype and check any drug yourself.

Engine verification

Phenotype logic is unit-tested against known-correct CPIC outcomes — 21/21 passing (e.g. CYP2C19 *2/*2 → Poor Metabolizer; CYP2D6 activity-score 3.0 → Ultrarapid; DPYD activity-score 1.5 → Intermediate).

Run locally

Everything is a single, dependency-free HTML file. Open directly, or serve:

python3 -m http.server 8080
# → http://localhost:8080/          (landing)
# → http://localhost:8080/app.html  (engine)
# → http://localhost:8080/deck.html (deck)

Positioning

Haplo monetizes the missing interpretation layer: CPIC/PharmGKB publish free, authoritative gene–drug guidelines, but the independent clinics and pharmacies where most prescribing happens can't operationalize them. Haplo is lab-agnostic (any test, any panel), standalone (no EHR project to start), and priced per clinic (~$2k/month) — below the cost of a single preventable adverse drug event. See docs/market-research.md.

Disclaimer

Haplo provides clinical decision support based on published CPIC/DPWG/FDA pharmacogenomic guidelines. It supports, and does not replace, the judgment of a licensed prescriber. Genotypes, phenotypes, and reports shown here are illustrative for this preview and must not be used for real clinical decisions.

License

MIT © 2026 Haplo. See LICENSE. Underlying pharmacogenomic guidance is the work of CPIC and PharmGKB.

About

Haplo — the genomic safety layer for every prescription. Lab-agnostic CPIC-based pharmacogenomic decision support.

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