This repository contains the reproducible computational workflow, analytical outputs, figures, manuscript drafts, and supplementary architecture for a single-author study of PTGS1/PTGS2 evolutionary pharmacogenomics.
The study integrates global human genetic variation, transcript-aware annotation, population differentiation metrics, functional-domain mapping, structural modeling, docking analysis, and signal-peptide biogenesis proxies to compare PTGS1 and PTGS2 as distinct evolutionary pharmacogenomic systems.
The analysis supports a topology-aware model in which PTGS1 diversification preferentially intersects signal-peptide/biogenesis-associated architecture, whereas PTGS2 diversification converges on catalytic-channel pharmacogenomic remodeling.
data/ Reference and source data
docs/ Manuscript drafts, methods notes, reference governance, and supplementary planning
results/tables/ Processed analytical tables and supplementary datasets
results/figures/ Figure panels, composites, and graphical abstract outputs
scripts/bash/ Bash workflow scripts
scripts/python/ Python analysis and figure-generation scripts
envs/ Environment files