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@GMELab Genetic and Molecular Epidemiology Laboratory

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    16 repositories

    • RV-EXCALIBER-v2

      Public
      Shell
      •
      GNU General Public License v3.0
      •0•0•0•0•Updated Aug 28, 2026Aug 28, 2026

    • RovHer

      Public
      A heritability-optimized scoring method using multivariate adaptive regression splines that incorporates 75 variant- and gene-level features. RovHer leverages e…
      bioinformaticsgeneticscomplex-traits
      bioinformaticsgeneticscomplex-traitsheritabilityrare-variants
      R
      •0•1•0•0•Updated Aug 15, 2026Aug 15, 2026

    • EX-TERR

      Public
      An R package for polygenic risk score (PRS) generation that applies multivariate adaptive regression splines (MARS) to integrate genetic information from multip…
      R
      •
      MIT License
      •0•0•0•0•Updated Jun 17, 2026Jun 17, 2026

    • lmutils

      Public
      Utilities for linear regression-based statistical computation, particularly in the same vein as methods like MonsterLM and RARity
      Rust
      •
      MIT License
      •0•2•0•0•Updated Dec 15, 2025Dec 15, 2025

    • lmutils.r

      Public
      Tools for blazingly fast statistical analysis in R
      Rust
      •0•2•0•0•Updated Dec 15, 2025Dec 15, 2025

    • docker

      Public
      Dockerfile
      •0•0•0•0•Updated Oct 25, 2025Oct 25, 2025

    • StratMRAlgo

      Public
      An R-based software package which automates a stratified Mendelian randomization (MR) algorithm designed to identify effect modifiers of causal relationships
      R
      •
      GNU General Public License v3.0
      •1•1•0•0•Updated Sep 29, 2025Sep 29, 2025

    • longevityMR

      Public
      Scripts and Supplemental data from Mendelian Randomization analyses of risk factors and diseases on parental longevity, including sex-specific effects.
      MIT License
      •0•0•0•0•Updated Sep 24, 2025Sep 24, 2025

    • plots.r

      Public
      Generate beautiful forest plots with ease
      R
      •
      Other
      •0•0•0•0•Updated Jul 17, 2025Jul 17, 2025

    • col-combiner

      Public
      Rust
      •
      MIT License
      •0•0•0•0•Updated Jun 12, 2025Jun 12, 2025

    • RARity

      Public
      A method to estimate rare variant heritability. Its versatility lies in the ability to estimate both gene-level and exome-wide heritability, in a fast, accurate…
      R
      •
      GNU General Public License v3.0
      •0•3•0•0•Updated Jan 15, 2025Jan 15, 2025

    • phewmr-filter-snps

      Public
      Rust
      •
      MIT License
      •0•0•0•0•Updated Dec 22, 2024Dec 22, 2024

    • MonsterLM

      Public
      A method to estimate the proportion of variance explained by heritability and gene-by-environment interactions, in a fast, accurate, efficient, and unbiased man…
      Shell
      •
      GNU General Public License v3.0
      •0•1•2•0•Updated Apr 3, 2024Apr 3, 2024

    • RV-EXCALIBER

      Public
      A methodological framework to conduct a calibrated gene-based rare variant association test by leveraging the genome aggregation database (gnomAD) as an externa…
      Shell
      •
      GNU General Public License v3.0
      •1•9•1•0•Updated Mar 4, 2023Mar 4, 2023

    • AutoMitoC

      Public
      Automatic Mitochondrial DNA Copy Number (mtDNA-CN) Pipeline to infer mtDNA-CN from SNP array intensities
      R
      •
      GNU General Public License v3.0
      •3•4•1•0•Updated Feb 14, 2022Feb 14, 2022

    • GraBLD

      Public
      an R based software package that makes polygenic traits prediction using gradient boosted and LD adjusted gene score weights.
      R
      •
      Other
      •4•10•0•0•Updated Apr 9, 2019Apr 9, 2019
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