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mmasnoon/README.md

Hi, I'm Mantuka Masnoon Umama 👋

Microbiology Graduate | Bioinformatics | Molecular Biology

I'm a Microbiology graduate from North South University with an interest in bioinformatics, molecular biology, genomics, transcriptomics, and structural bioinformatics.

I enjoy combining biological knowledge with computational approaches to investigate molecular mechanisms, analyze biological data, and develop reproducible research workflows.


🔬 Research Interests

  • 🧬 Bioinformatics & Computational Biology
  • 🧪 Molecular Biology
  • 🦠 Microbiology & Infectious Diseases
  • 🧬 Genomics & Transcriptomics
  • 🧫 Microbial Genomics
  • 🧩 Structural Bioinformatics
  • 📊 Biological Data Analysis

🛠️ Tools & Technologies

Programming & Data Analysis

R Python Bash Linux

Bioinformatics

Salmon FastQC MultiQC QIIME 2 DADA2

Molecular & Structural Analysis

BLAST MAFFT ClustalW MUSCLE MEGA AlphaFold2 ColabFold

Data & Version Control

Git GitHub Conda Pixi


🧬 Featured Research

Undergraduate Thesis

Redefining GOLT1B: A Dual-Pass SNARE-Like Protein with a Kingdom-Specific Q/R Transition and Structural Basis for IFITM3 Interaction

My undergraduate research focused on the sequence, evolutionary, structural, and functional characterization of GOLT1B, combining comparative sequence analysis, phylogenetics, domain analysis, membrane topology prediction, subcellular localization prediction, and protein structure modeling.

Methods & Tools:

  • Sequence retrieval & comparative analysis
  • BLAST
  • Multiple sequence alignment
  • Phylogenetic analysis
  • Ancestral state reconstruction
  • Domain & motif analysis
  • Transmembrane topology prediction
  • Protein localization prediction
  • AlphaFold2 / ColabFold

📊 Current Computational Work

I'm currently building reproducible workflows for RNA-seq data analysis, including:

  • FASTQ quality control
  • Transcript quantification
  • Salmon indexing & quantification
  • MultiQC-based quality assessment
  • R-based downstream analysis
  • Differential gene expression
  • Data visualization

🎓 Education

B.Sc. in Microbiology North South University 2021 – 2026

**Cum Laude


📌 What You'll Find Here

This GitHub profile contains projects involving:

📁 Bioinformatics workflows 📊 Transcriptomic data analysis 🧬 Molecular sequence analysis 🧩 Structural bioinformatics 🦠 Microbiology research 💻 Reproducible computational pipelines


📫 Connect With Me


Turning biological questions into computational insights. 🧬

Pinned Loading

  1. Breast-Cancer-GE-Meta-Analysis Breast-Cancer-GE-Meta-Analysis Public

    Meta-analysis of bulk RNA-seq data from two independent GEO breast cancer datasets, combining effect sizes via random-effects modeling to identify replicated DEGs, pathways, and PPI network hubs di…

    R