My model is based on the causal loop diagram of MDD proposed in:
Wittenborn AK, Rahmandad H, Rick J, Hosseinichimeh N. Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder. Psychol Med. 2016 Feb;46(3):551-62. doi: 10.1017/S0033291715002044. Epub 2015 Dec 1. PMID: 26621339; PMCID: PMC4737091.
And in the approach to model the functional relationships of the proposed causal loop diagram, my attempt is influenced by:
Robinaugh, D., Haslbeck, J. M. B., Waldorp, L., Kossakowski, J. J., Fried, E. I., Millner, A., … Borsboom, D. (2019, May 29). Advancing the Network Theory of Mental Disorders: A Computational Model of Panic Disorder. https://doi.org/10.31234/osf.io/km37w
and
Wang, S. B., Robinaugh, D., Millner, A., Fortgang, R., & Nock, M. (2023, September 24). Mathematical and Computational Modeling of Suicide as a Complex Dynamical System. https://doi.org/10.31234/osf.io/b29cs; Code available here
References to the numbers are in Appendix of (Wittenborn et al. 2016).
This is my slightly modified version of the feedback mechanisms in Major Depressive Disorder (MDD). Green arrows with empty head reduce and red arrows with filled head increase variable values. The components can roughly be grouped into “Psychological” (green), “Neurobiological” (purple) and fixed variables (light orange). Variables with dashed borders change over weeks/months and variables with solid border change over minutes.
