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Refactor constraint pipeline to per-base architecture with v4.1.1 support - #51

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jkgoodrich wants to merge 40 commits into
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jg/switch_constraint_to_per_base
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Refactor constraint pipeline to per-base architecture with v4.1.1 support#51
jkgoodrich wants to merge 40 commits into
mainfrom
jg/switch_constraint_to_per_base

Split rank and bin annotations into a separate constraint metrics phase

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