OmiGA (Omics Genetic Analysis) is a toolkit designed to ultra-efficient genetic analysis for high-throughput measurements of omics, such as gene expression, alternative splicing, DNA methylation, metabolites, Microbiome, protein abundance, and so forth. Additionally, OmiGA is applicable to genome-wide association study (GWAS) for complex traits. For detailed documentation, please click here.
OmiGA currently supports the following analyses:
Molecular Quantitative Trait Locus (molQTL) mapping
- Cis-QTL, independent cis-QTL, interaction cis-QTL, trans-QTL
- Linear mixed model and linear model
- Additive and/or non-additive effects
- Calculating genetic relationship matrix
- Automatically choosing covariates using PCA analysis for genotype and phenotype data
Heritability analysis of molecular traits
- Partitioning additive and/or non-additive heritability
- Estimating the cis-, trans-heritability, and global heritability
To use OmiGA, follow these steps:
Copyright (C) 2024, Jinyan Teng and team.
The OmiGA source code repository is free software, distributed under the GNU General Public License v3.0 (GPLv3). For detailed licensing information, please consult the LICENSE file.
All the files in this project are allowed to be copied, modified, and distributed for educational, research and non-profit purposes, without charge and without a written agreement, provided that this copyright notice are included in all copies. If you intend to use this project for commercial purposes, kindly contact the author for authorization prior to use.
To acknowledge this software, please cite our preprint (2024): https://doi.org/10.1101/2024.12.19.629424. For questions, please email us at jinyan.teng@scau.edu.cn