NeuroCross is a personal research project, forked from the SENACYT blood-brain barrier (BBB) simulator and now developed independently. It models the adhesion of functionalized nanocarriers (currently liposomes only) to the luminal surface of the BBB, using DLVO/PMF physics and Boltzmann statistics, in the context of therapies for Multiple Sclerosis.
NeuroCross is not a validated quantitative predictor of drug delivery or therapeutic efficacy — no published literature currently anchors adhesion or permeation outputs end-to-end against real measurements, and no confirmed passive transcytosis mechanism exists for unligated liposomes. Given this, the project's goal is deliberately scoped as a physical triage tool and literature gap map: it screens out candidates that are physically unviable in adhesion or circulation survival, and documents — gate by gate — what is backed by real experimental contrast, what is borrowed by analogy, and what has no physics implemented at all. A gate without real contrast never returns FAIL, only UNKNOWN.
Try it live: https://rosakops.github.io/NeuroCross/triage/
Or run it locally: the route to access the simulator is /triage/index.html, served over HTTP (not opened directly as a file — the engine's Python files are blocked by CORS otherwise). From the repo root: python3 -m http.server 8000 and open http://localhost:8000/triage/.
⚠️ Disclaimer
This project is a work in progress. It does not predict therapeutic efficacy or final parenchymal delivery — that is explicitly out of scope. The underlying models, simulations, and parameters have not been fully validated or benchmarked against experimental data. As such, this software should not be cited or relied upon as a definitive scientific reference for clinical or academic publications at this stage.Note: Currently, the simulator interface only supports Spanish.