The NeuroTune Simulation Package provides a simplified implementation of the Connor-Stevens model of neuronal dynamics. It incorporates the key ion currents involved in action potential generation, focusing on Leak, Na⁺, K⁺, A-type K⁺, and T-type Ca²⁺ channels. This model does not include dynamic conductance changes and operates with pre-set ion channel parameters, in reference to Dayan & Abbott, Chapter 6.
Key Features:
- Simulate action potentials based on Hodgkin-Huxley and Connor-Stevens models.
- Model components include Leak, Na⁺, K⁺, A-type K⁺, and T-type Ca²⁺ currents.
- This simulator only gives the user define the initial conditions; initial voltage, injected current,and total simulation time.
Usage:
- Define the initial conditions (initial voltage and injected current).
- Set the total simulation time and specify the timing of current injections.
- Click Run NeuroTune to simulate and visualize the action potential.
- The results are displayed on the built-in plotting interface.
When there is no input current and the initial voltage is set to V=-68mV and as expected there is no neural activity.
Increase in the input leads to increased neural activity.
Default parameters reproduce the example shown in Dayan & Abbott, Figure 6.2.
In this example, the current input is set to zero, however the membrane potential is set to -92mV that is highly hyperpolarized.
This hyperpolarization activates: (1) the A-current through the transient K+ conductane, and (2) the T-type Ca2+ conductances. The delay in the spike generation is due to the activated A-currents.
Resources: Dayan, P., & Abbott, L. F. (2001). Theoretical Neuroscience: Computational and Mathematical Modeling of Neural Systems. Chapter 6. MIT Press.