Standardize readme

README.md

@@ -0,0 +1,45 @@
+This model is associated with the paper:
+
+**A model of spike initiation in neocortical pyramidal neurons**
+Z. F. Mainen, J. Joerges, J. R. Huguenard and T. J. Sejnowski
+*Neuron* 15, 1427-1439 (1995)
+
+Please see [http://www.cnl.salk.edu/~zach/methods.html](http://www.cnl.salk.edu/~zach/methods.html)
+where a full text (postscript format) copy of the paper and copies of the model for early versions of NEURON is available.
+
+This model contains compartmental models of a reconstructed neocortical neuron with active dendritic currents using NEURON. This paper examines the paradox that although spikes can back-propagate from the soma into dendrites with spike amplitudes maintained in dendrites by voltage-gated channels it rarely occurs that spikes are initiated in dendrites in these cells. The model suggests that dendritic channel inactivation and source-load considerations are contributing factors. See the paper for more details.
+
+This package is written in the NEURON simulation program written by Michael Hines and available on the internet at:
+[http://www.neuron.yale.edu/](http://www.neuron.yale.edu/)
+
+## HOW TO RUN (under NEURON version 5 and higher)
+
+To compile the demo, NEURON and INTERVIEWS must be installed and working on the machine you are using.
+
+When the spikeinit.zip file is unzipped it creates a spikeinit directory which contains the hoc and mod NEURON program files. Change directory to spikeinit.
+
+### under UNIX:
+
+Just type `nrnivmodl` to compile the mechanisms given in the mod files in the directory.
+
+Execute the first figure demo program by typing:
+
+```
+nrngui demo.hoc
+```
+
+Continue below under **back to any platform:**
+
+### under MS WINDOWS (PC):
+
+Press Start button (lower left corner) and then press Programs and then NEURON and then mknrndll. Change directory to where the zip file was unzipped and enter the directory that came with the zip file (spikeinit). Press the nrnmech.dll button.
+
+You can start the simulation by a double click on
+`demo.hoc`
+in Windows Explorer.
+
+The simulation produces fig 3 from the paper.
+
+---
+
+2025-05-27 – Standardized to Markdown