Simulation of SDH Network Model

To simulate the Spinal Dorsal Horn Network Model:

1. Install python3 (from https://www.python.org/downloads/)

Then open the terminal (for Macs) and run the following commands: 2. Install NEURON and NetPyNE:

pip3 install neuron pip3 install netpyne

3. Change to the directory containing SDH model files. Example:

cd ~/Downloads/SDHmodel

4. Compile the mod files:

nrnivmodl mods

5. Run the script to initialize the model:

nrniv -python init_mechanical.py

Running the model scripts (Step 5) can also be done in the interative Python (IPython) shell:

ipython run init_mechanical.py

6. Data and figures will save to SDHmodel/data directory

The output of this code reproduces the raster plot (Fig. 3A) and synaptic connectivity matrix (Fig. 3D) from Sekiguchi et al. (2021).