Skip to content
View Hemalatha18-bio's full-sized avatar

Block or report Hemalatha18-bio

Block user

Prevent this user from interacting with your repositories and sending you notifications. Learn more about blocking users.

You must be logged in to block users.

Content in all repositories owned by your account will be closed.
Maximum 250 characters. Please don’t include any personal information such as legal names or email addresses. Markdown is supported. This note will only be visible to you.
Report abuse

Contact GitHub support about this user’s behavior. Learn more about reporting abuse.

Report abuse
Hemalatha18-bio/README.md

Hi, I'm Hemalatha Ponnam 👋

Bioinformatics & Computational Biology | Python | NGS | Metagenomics | Proteomics | Machine Learning

I build reproducible computational workflows for biological data analysis, with interests spanning genomics, metagenomics, proteomics, machine learning, workflow automation, and research software practices.

Core Skills

  • Programming & data analysis: Python, pandas, scikit-learn, matplotlib
  • Bioinformatics: NGS, FASTQ processing, gene-expression analysis, metagenomics, proteomics
  • Machine learning: classification, feature importance, model evaluation, explainability
  • Workflow & reproducibility: Snakemake, SLURM/HPC, Git, GitHub Actions, pytest
  • Data formats & tools: FASTQ, CSV/TSV, JSON, parquet, DIA-NN-style outputs

Featured Projects

🧬 Colorectal Cancer Metagenomics Pipeline

Reproducible metagenomics and machine-learning workflow with leakage-aware preprocessing, real output visualization, testing, GitHub Actions CI, Snakemake, and SLURM/HPC examples.

View repository

🧠 Alzheimer's Gene Prediction with Machine Learning

Gene-expression ML project using leakage-safe preprocessing, multiple classifiers, exported evaluation metrics, SHAP-based explainability, testing, CI, Snakemake, and SLURM.

View repository

🧪 DIA-PASEF Proteomics Analysis

Reproducible DIA-NN post-processing and QC workflow with CLI tools, validation, generated QC visualization, testing, GitHub Actions, Snakemake, and SLURM examples.

View repository

🧬 FASTQ Interleaving Utility

Tested Python CLI for paired-end FASTQ interleaving with gzip support, unequal-pair detection, optional mate-ID validation, synthetic examples, and CI.

View repository

What I Focus On

I am especially interested in building analysis workflows that are clear, reproducible, testable, and suitable for collaborative scientific environments. My portfolio projects emphasize not only biological analysis, but also software quality through validation, automated tests, CI, workflow management, and HPC-aware execution.

Current Interests

  • Bioinformatics and computational biology
  • Genomics and transcriptomics
  • Metagenomics and microbiome analysis
  • Proteomics
  • Machine learning for biological data
  • Reproducible scientific computing
  • Research workflow automation

GitHub Portfolio

My repositories are organized as public portfolio demonstrations. When original research data are unavailable, restricted, unpublished, or lab-owned, I use small example or synthetic datasets and clearly separate public reproducible code from broader project context.

Pinned Loading

  1. colorectal-cancer-metagenomics-pipeline colorectal-cancer-metagenomics-pipeline Public

    Reproducible metagenomics and machine-learning workflow with Snakemake, SLURM, testing, and CI.

    Python

  2. alzheimers-gene-prediction-ml alzheimers-gene-prediction-ml Public

    Leakage-aware gene-expression ML pipeline with explainability, workflow automation, testing, and CI.

    Python

  3. dia-pasef-proteomics-analysis dia-pasef-proteomics-analysis Public

    Reproducible DIA-NN proteomics post-processing and QC workflow with Python, Snakemake, SLURM, and CI.

    Python

  4. BCB5250_FASTQ_Interleaving BCB5250_FASTQ_Interleaving Public

    Tested Python CLI for paired-end FASTQ interleaving with gzip support and mate validation.

    Python