diff --git a/CHANGES.rst b/CHANGES.rst
index ad6d698341a..4598ce153c3 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -13,6 +13,11 @@ Bugs fixed
   English stemmer) and Dutch (which uses the Dutch Porter stemmer).
   Patch by Hugo van Kemenade
 
+* #14576: autodoc: Fix ``IndexError`` when an ``autodoc-process-signature``
+  handler returns a signature for a data or type object, which are documented
+  without one. The object was then rendered without its docstring.
+  Patch by Jhon Alvarez
+
 
 Release 9.1.0 (released Dec 31, 2025)
 =====================================
diff --git a/sphinx/ext/autodoc/_dynamic/_signatures.py b/sphinx/ext/autodoc/_dynamic/_signatures.py
index de55c44fb9f..1a8563c84c6 100644
--- a/sphinx/ext/autodoc/_dynamic/_signatures.py
+++ b/sphinx/ext/autodoc/_dynamic/_signatures.py
@@ -125,7 +125,10 @@ def _format_signatures(
     ):
         if len(result) == 2 and isinstance(result[0], str):
             args, retann = result
-            signatures[0] = (args, retann if isinstance(retann, str) else '')
+            # Data and type objects skip signature extraction, so *signatures*
+            # may still be empty here. A handler is free to return a signature
+            # for them anyway, and slice assignment stores it either way.
+            signatures[:1] = [(args, retann if isinstance(retann, str) else '')]
 
     if props.obj_type in {'module', 'data', 'type'}:
         signatures[1:] = ()  # discard all signatures save the first
diff --git a/tests/test_ext_autodoc/test_ext_autodoc_signatures.py b/tests/test_ext_autodoc/test_ext_autodoc_signatures.py
index f3f87e4d38a..cc1d6e696a5 100644
--- a/tests/test_ext_autodoc/test_ext_autodoc_signatures.py
+++ b/tests/test_ext_autodoc/test_ext_autodoc_signatures.py
@@ -289,6 +289,24 @@ def foo1(self, b, *c):  # type: ignore[no-untyped-def]
     assert format_sig('method', 'bar', H.foo1, events=events) == ('42', '')
 
 
+def test_format_signatures_event_handler_on_data() -> None:
+    # A data object skips signature extraction, so *signatures* is still empty
+    # when the event fires. A handler may return a signature for it anyway.
+    def process_signature(*args: Any) -> tuple[str, str | None]:
+        return '()', None
+
+    events = FakeEvents()
+    events.connect('autodoc-process-signature', process_signature)
+
+    class CallableData:
+        class_var: Any
+
+        def __call__(self) -> None:
+            pass
+
+    assert format_sig('data', 'sig_bug', CallableData(), events=events) == ('()', '')
+
+
 def test_format_functools_partial_signatures() -> None:
     # test functions created via functools.partial
     from functools import partial