diff --git a/AUTHORS.rst b/AUTHORS.rst
index b702c64c0f9..31d6ec3cbf5 100644
--- a/AUTHORS.rst
+++ b/AUTHORS.rst
@@ -120,6 +120,7 @@ Contributors
 * Tim Hoffmann -- theme improvements
 * Tim Pillinger -- documentation improvements
 * Valentin Heinisch -- warning types improvement
+* Vedant Kumar -- autodoc fixes
 * Victor Wheeler -- documentation improvements
 * Vince Salvino -- JavaScript search improvements
 * Will Maier -- directory HTML builder
diff --git a/CHANGES.rst b/CHANGES.rst
index ad6d698341a..7a2ff711aad 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -13,6 +13,11 @@ Bugs fixed
   English stemmer) and Dutch (which uses the Dutch Porter stemmer).
   Patch by Hugo van Kemenade
 
+* #14576: autodoc: Fix an :py:exc:`IndexError` when an
+  ``autodoc-process-signature`` event handler returns a signature
+  for a data object.
+  Patch by Vedant Kumar.
+
 
 Release 9.1.0 (released Dec 31, 2025)
 =====================================
diff --git a/sphinx/ext/autodoc/_dynamic/_signatures.py b/sphinx/ext/autodoc/_dynamic/_signatures.py
index de55c44fb9f..8586799d018 100644
--- a/sphinx/ext/autodoc/_dynamic/_signatures.py
+++ b/sphinx/ext/autodoc/_dynamic/_signatures.py
@@ -125,7 +125,14 @@ def _format_signatures(
     ):
         if len(result) == 2 and isinstance(result[0], str):
             args, retann = result
-            signatures[0] = (args, retann if isinstance(retann, str) else '')
+            replacement = (args, retann if isinstance(retann, str) else '')
+            if signatures:
+                signatures[0] = replacement
+            else:
+                # No signature was introspected (e.g. for data objects),
+                # but an event handler returned a replacement signature.
+                # See: https://github.com/sphinx-doc/sphinx/issues/14576
+                signatures.append(replacement)
 
     if props.obj_type in {'module', 'data', 'type'}:
         signatures[1:] = ()  # discard all signatures save the first
diff --git a/tests/test_ext_autodoc/test_ext_autodoc_signatures.py b/tests/test_ext_autodoc/test_ext_autodoc_signatures.py
index f3f87e4d38a..dd00d11070c 100644
--- a/tests/test_ext_autodoc/test_ext_autodoc_signatures.py
+++ b/tests/test_ext_autodoc/test_ext_autodoc_signatures.py
@@ -355,3 +355,56 @@ def func(x: int, y: int) -> int:  # type: ignore[empty-body]
     assert captured == [
         (app, 'function', '.func', func, options, '(x: int, y: int)', 'int')
     ]
+
+
+def test_autodoc_process_signature_data_object() -> None:
+    # https://github.com/sphinx-doc/sphinx/issues/14576
+    # No signature is introspected for data objects, but a handler for
+    # ``autodoc-process-signature`` may still return a replacement
+    # signature; this must not raise an IndexError.
+    from sphinx.ext.autodoc._property_types import _AssignStatementProperties
+
+    def process_signature(*args: Any) -> tuple[str, str | None]:
+        return '()', None
+
+    events = FakeEvents()
+    events.connect('autodoc-process-signature', process_signature)
+
+    class SigBug:
+        class_var: Any
+
+        def __call__(self) -> None:
+            pass
+
+    sig_bug = SigBug()
+
+    props = _AssignStatementProperties(
+        obj_type='data',
+        module_name='',
+        parts=('sig_bug',),
+        docstring_lines=(),
+        value=sig_bug,
+        annotation='',
+        class_var=False,
+        instance_var=False,
+        _obj=sig_bug,
+        _obj___module__=None,
+        _obj_is_generic_alias=False,
+        _obj_is_attribute_descriptor=False,
+        _obj_is_mock=False,
+        _obj_is_sentinel=None,
+        _obj_repr_rst='',
+        _obj_type_annotation=None,
+    )
+
+    signatures = _format_signatures(
+        autodoc_annotations={},
+        config=_AutodocConfig(),
+        docstrings=None,
+        events=events,
+        get_attr=safe_getattr,
+        options=_AutoDocumenterOptions(),
+        parent=None,
+        props=props,
+    )
+    assert signatures == [('()', '')]