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How to calculate the clonal frequency? #4

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@Ethan5923

Dear Sir/Ma'am,

I'm very interested in your TIRTL-seq. In your Nature Methods paper, it shows that TIRTL-seq can give me both precise clonal frequency estimation and accurate TCR chain pairing. I can successfully run the example code in GitHub. But I don't find documents about the way to calculate the clonal frequency. Could you please give me some idea?

Thank you!

Best regards,
Ethan

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