diff --git a/hubspot_sync/task_helpers.py b/hubspot_sync/task_helpers.py
index 25d574d830..1b17a7dc13 100644
--- a/hubspot_sync/task_helpers.py
+++ b/hubspot_sync/task_helpers.py
@@ -4,6 +4,7 @@
 
 from django.conf import settings
 
+from courses.models import CourseRun, ProgramEnrollment
 from courses.utils import is_uai_order
 from ecommerce.models import Order, Product
 from hubspot_sync import tasks
@@ -41,6 +42,21 @@ def sync_hubspot_user(user: User):
             )
 
 
+def _order_is_for_program_enrolled_course(order: Order) -> bool:
+    """Return True if any line is a course run belonging to a program the purchaser is already enrolled in."""
+    course_ids = [
+        line.purchased_object.course_id
+        for line in order.lines.all()
+        if line.purchased_object and isinstance(line.purchased_object, CourseRun)
+    ]
+    if not course_ids:
+        return False
+    return ProgramEnrollment.objects.filter(
+        user=order.purchaser,
+        program__all_requirements__course__in=course_ids,
+    ).exists()
+
+
 def sync_hubspot_deal(order: Order):
     """
     Trigger celery task to sync an order to Hubspot if it has lines.
@@ -60,6 +76,15 @@ def sync_hubspot_deal(order: Order):
         )
         return
 
+    if _order_is_for_program_enrolled_course(order):
+        log.info(
+            "Skipping HubSpot deal sync for order %d: user %s (user_id=%d) is already enrolled in a program containing this course",
+            order.id,
+            order.purchaser.edx_username or order.purchaser.email,
+            order.purchaser.id,
+        )
+        return
+
     if order.lines.first() is not None:
         is_uai = is_uai_order(order)
 
diff --git a/hubspot_sync/task_helpers_test.py b/hubspot_sync/task_helpers_test.py
index d71426aa03..340232477f 100644
--- a/hubspot_sync/task_helpers_test.py
+++ b/hubspot_sync/task_helpers_test.py
@@ -1,9 +1,13 @@
 """Tests for hubspot_sync.task_helpers"""
 
 import pytest
+import reversion
+from reversion.models import Version
 
 from b2b.factories import ContractPageFactory
-from ecommerce.factories import ProductFactory
+from courses.factories import CourseRunFactory, ProgramEnrollmentFactory, ProgramFactory
+from courses.models import ProgramRequirementNodeType
+from ecommerce.factories import LineFactory, OrderFactory, ProductFactory
 from hubspot_sync.task_helpers import (
     sync_hubspot_cart_add,
     sync_hubspot_deal,
@@ -172,6 +176,100 @@ def test_sync_hubspot_product(mocker, mock_exception_log, raise_exc):
         mock_exception_log.assert_not_called()
 
 
+def test_sync_hubspot_deal_skips_for_course_in_enrolled_program(mocker, settings):
+    """sync_hubspot_deal should skip if the order is for a course run in a program the user is enrolled in."""
+    settings.MITOL_HUBSPOT_API_PRIVATE_TOKEN = "faketoken"  # noqa: S105
+
+    mock_sync = mocker.patch(
+        "hubspot_sync.task_helpers.tasks.sync_deal_with_hubspot_targeted.apply_async"
+    )
+    mocker.patch("hubspot_sync.task_helpers.is_uai_order", return_value=False)
+
+    course_run = CourseRunFactory.create()
+    program = ProgramFactory.create()
+    program.requirements_root.add_child(
+        node_type=ProgramRequirementNodeType.COURSE,
+        course=course_run.course,
+    )
+
+    with reversion.create_revision():
+        product = ProductFactory.create(purchasable_object=course_run)
+
+    order = OrderFactory.create()
+    LineFactory.create(
+        order=order,
+        product_version=Version.objects.get_for_object(product).first(),
+        purchased_object=course_run,
+    )
+    ProgramEnrollmentFactory.create(user=order.purchaser, program=program)
+
+    sync_hubspot_deal(order)
+
+    mock_sync.assert_not_called()
+
+
+def test_sync_hubspot_deal_proceeds_for_course_not_in_program(
+    mocker, mock_exception_log, settings
+):
+    """sync_hubspot_deal should proceed if the order is for a course not in any program."""
+    settings.MITOL_HUBSPOT_API_PRIVATE_TOKEN = "faketoken"  # noqa: S105
+
+    mock_sync = mocker.patch(
+        "hubspot_sync.task_helpers.tasks.sync_deal_with_hubspot_targeted.apply_async"
+    )
+    mocker.patch("hubspot_sync.task_helpers.is_uai_order", return_value=False)
+
+    course_run = CourseRunFactory.create()
+
+    with reversion.create_revision():
+        product = ProductFactory.create(purchasable_object=course_run)
+
+    order = OrderFactory.create()
+    LineFactory.create(
+        order=order,
+        product_version=Version.objects.get_for_object(product).first(),
+        purchased_object=course_run,
+    )
+
+    sync_hubspot_deal(order)
+
+    mock_sync.assert_called_once()
+
+
+def test_sync_hubspot_deal_proceeds_when_not_enrolled_in_program(
+    mocker, mock_exception_log, settings
+):
+    """sync_hubspot_deal should proceed if the user is not enrolled in the program containing this course."""
+    settings.MITOL_HUBSPOT_API_PRIVATE_TOKEN = "faketoken"  # noqa: S105
+
+    mock_sync = mocker.patch(
+        "hubspot_sync.task_helpers.tasks.sync_deal_with_hubspot_targeted.apply_async"
+    )
+    mocker.patch("hubspot_sync.task_helpers.is_uai_order", return_value=False)
+
+    course_run = CourseRunFactory.create()
+    program = ProgramFactory.create()
+    program.requirements_root.add_child(
+        node_type=ProgramRequirementNodeType.COURSE,
+        course=course_run.course,
+    )
+
+    with reversion.create_revision():
+        product = ProductFactory.create(purchasable_object=course_run)
+
+    order = OrderFactory.create()
+    LineFactory.create(
+        order=order,
+        product_version=Version.objects.get_for_object(product).first(),
+        purchased_object=course_run,
+    )
+    # Intentionally do not enroll the user in the program
+
+    sync_hubspot_deal(order)
+
+    mock_sync.assert_called_once()
+
+
 @pytest.mark.parametrize("raise_exc", [True, False])
 def test_sync_hubspot_cart_add(mocker, mock_exception_log, user, raise_exc):
     """sync_hubspot_cart_add should call sync_cart_add_event_with_hubspot.apply_async and log any exception"""