diff --git a/src/jobflow/core/job.py b/src/jobflow/core/job.py
index d00501b2..18c11337 100644
--- a/src/jobflow/core/job.py
+++ b/src/jobflow/core/job.py
@@ -28,6 +28,23 @@
 logger = logging.getLogger(__name__)
 
 
+def _replace_job_or_flow_with_output(value):
+    """Replace Jobs and Flows in nested containers with their outputs."""
+    from jobflow.core.flow import Flow
+
+    if isinstance(value, (Job, Flow)):
+        return value.output
+    if isinstance(value, list):
+        return [_replace_job_or_flow_with_output(item) for item in value]
+    if isinstance(value, tuple):
+        return tuple(_replace_job_or_flow_with_output(item) for item in value)
+    if isinstance(value, dict):
+        return {
+            key: _replace_job_or_flow_with_output(item) for key, item in value.items()
+        }
+    return value
+
+
 @dataclass
 class JobConfig(MSONable):
     """
@@ -213,6 +230,10 @@ def get_job(*args, **kwargs) -> Job:
                         f = met
                         args = args[1:]
 
+            if _current_flow_context.get() is not None:
+                args = _replace_job_or_flow_with_output(args)
+                kwargs = _replace_job_or_flow_with_output(kwargs)
+
             return Job(
                 function=f, function_args=args, function_kwargs=kwargs, **job_kwargs
             )
@@ -604,7 +625,7 @@ def run(self, store: jobflow.JobStore, job_dir: Path = None) -> Response:
         from datetime import datetime
 
         from jobflow import CURRENT_JOB
-        from jobflow.core.flow import get_flow
+        from jobflow.core.flow import flow_build_context, get_flow
         from jobflow.core.schemas import JobStoreDocument
 
         index_str = f", {self.index}" if self.index != 1 else ""
@@ -626,12 +647,17 @@ def run(self, store: jobflow.JobStore, job_dir: Path = None) -> Response:
         if bound is not None and not isinstance(bound, types.ModuleType):
             function = types.MethodType(function, bound)
 
-        response = function(*self.function_args, **self.function_kwargs)
+        dynamic_children = []
+        with flow_build_context(dynamic_children):
+            response = function(*self.function_args, **self.function_kwargs)
         response = Response.from_job_returns(
             response, self.output_schema, job_dir=job_dir
         )
 
         if response.replace is not None:
+            response.replace = _expand_dynamic_dependencies(
+                response.replace, dynamic_children
+            )
             response.replace = prepare_replace(response.replace, self)
 
         if response.addition is not None:
@@ -1481,6 +1507,51 @@ def prepare_replace(
     return replace
 
 
+def _expand_dynamic_dependencies(replace, dynamic_children):
+    """Add dynamically created dependencies required by a replacement."""
+    from jobflow.core.flow import Flow
+
+    candidates = [child for child in dynamic_children if child.host is None]
+    if not candidates:
+        return replace
+
+    if isinstance(replace, dict):
+        explicit_jobs = list(replace.values())
+        output = {key: child.output for key, child in replace.items()}
+    elif isinstance(replace, (list, tuple)):
+        explicit_jobs = list(replace)
+        output = type(replace)(child.output for child in replace)
+    else:
+        explicit_jobs = [replace]
+        output = replace.output
+
+    def all_uuids(child):
+        if isinstance(child, Flow):
+            return set(child.all_uuids)
+        return {child.uuid}
+
+    explicit_uuids = set().union(*(all_uuids(child) for child in explicit_jobs))
+    required_uuids = set(explicit_uuids)
+
+    while True:
+        selected = [
+            child for child in candidates if all_uuids(child) & required_uuids
+        ]
+        expanded_uuids = set().union(
+            required_uuids, *(set(child.graph.nodes) for child in selected)
+        )
+        if expanded_uuids == required_uuids:
+            break
+        required_uuids = expanded_uuids
+
+    selected = [child for child in candidates if all_uuids(child) & required_uuids]
+    selected_uuids = set().union(*(all_uuids(child) for child in selected))
+    if selected_uuids.issubset(explicit_uuids):
+        return replace
+
+    return Flow(selected, output=output)
+
+
 def pass_manager_config(
     jobs: Job | jobflow.Flow | list[Job | jobflow.Flow],
     manager_config: dict[str, Any],
diff --git a/tests/core/test_job.py b/tests/core/test_job.py
index f9416221..c87f853b 100644
--- a/tests/core/test_job.py
+++ b/tests/core/test_job.py
@@ -230,6 +230,38 @@ def replace_list_flow():
     # currently output schema and metadata ignored for all but the last `store_inputs`
 
 
+def test_replace_response_collects_dynamic_dependencies():
+    """Test replacement jobs include dynamically created dependencies."""
+    from jobflow import Response, job, run_locally
+
+    @job
+    def add_job(a, b):
+        return a + b
+
+    @job
+    def multiply_job(value, factor):
+        return value * factor
+
+    @job
+    def make_dynamic_workflow():
+        add_job(100, 200)
+        first = add_job(1, 2)
+        final = multiply_job(first, 3)
+        return Response(replace=final)
+
+    dynamic_job = make_dynamic_workflow()
+    responses = run_locally(dynamic_job, ensure_success=True)
+
+    outputs = [
+        response.output
+        for index_to_response in responses.values()
+        for response in index_to_response.values()
+        if isinstance(response.output, int)
+    ]
+    assert sorted(outputs) == [3, 9]
+    assert len(responses) == 3
+
+
 def test_job_config(memory_jobstore):
     from jobflow import (
         CURRENT_JOB,