Population difference

[HongyanR]

Hi, a quick question: Can I use the trained .db files to predict expression level in the Chinese population? I noticed all your files are named "...imputed_europeans".

[hakyim]

Dear Hongyan as the file names suggest, the prediction models were training using predominantly European samples. We have performed some comparisons and found that the cross population is possible although we do lose some performance. This paper will give you a better sense of how much performance is lost https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007586 At the moment, we don't have GTEx scale data in other populations so my advice would be to use this and if possible also use a separate population specific model. I hope this helps Haky

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On Mon, Mar 4, 2019 at 8:55 PM HongyanR ***@***.***> wrote: Hi, a quick question: Can I use the trained .db files to predict expression level in the Chinese population? I noticed all your files are named "...imputed_europeans". — You are receiving this because you are subscribed to this thread. Reply to this email directly, view it on GitHub <#33>, or mute the thread <https://github.com/notifications/unsubscribe-auth/AC2ouScOvbqykekDV8zSI9tO5RX_Dvblks5vTdy5gaJpZM4bdpmq> .