diff --git a/docs/index.md b/docs/index.md
index 39dde0f..87ab78f 100644
--- a/docs/index.md
+++ b/docs/index.md
@@ -176,9 +176,35 @@ Lieer can be configured using `gmi set`. Use without any options to get a list o
 **`Replace slash with dot`** is used to replace the sub-label separator (`/`) with a dot (`.`). I think this is easier to work with. *Important*: See note below on [changing this setting after initial sync](#changing-ignored-tags-and-translation-after-initial-sync).
 
 **`Ignore tags (local)`** can be used to specify a list of tags which should not be synced from local to remote (e.g. [`new`](#usage)). In addition to the user-configured tags these tags are ignored: `'attachment', 'encrypted', 'signed', 'passed', 'replied', 'muted', 'mute', 'todo', 'Trash', 'voicemail'`. Some are special tags in notmuch and some are unsupported by GMail. See [Caveats](#caveats) below for more explanations. *Note:* This setting expects [_translated_ tags](#translation-between-labels-and-tags).
-  
+
   *Important*: See note below on [changing this setting after initial sync](#changing-ignored-tags-and-translation-after-initial-sync).
 
+**`Ignore tags regex (local)`** can be used to specify a list of regex patterns for tags which should not be synced from local to remote. This works in addition to the exact-match `Ignore tags (local)` setting. A tag is ignored if it matches ANY pattern (union/OR logic).
+
+Patterns use Python regex syntax with search matching (pattern can match anywhere in the tag). Patterns are case-sensitive.
+
+Example patterns:
+- `^draft-.*` - Ignores tags starting with "draft-" (e.g., `draft-v1`, `draft-reply`)
+- `.*-temp$` - Ignores tags ending with "-temp" (e.g., `work-temp`, `file-temp`)
+- `work/.*` - Ignores tags containing "work/" (e.g., `work/project`, `work/email`)
+- `^(temp|draft|wip)-` - Ignores tags starting with "temp-", "draft-", or "wip-"
+
+*Note:* This setting expects [_translated_ tags](#translation-between-labels-and-tags), same as `Ignore tags (local)`.
+
+*Important*: See note below on [changing this setting after initial sync](#changing-ignored-tags-and-translation-after-initial-sync). Invalid regex patterns will generate warnings but won't prevent the tool from running.
+
+Usage:
+```bash
+# Set regex patterns (comma-separated)
+gmi set --ignore-tags-regex-local "^draft-.*,^temp-.*,work/.*"
+
+# Clear regex patterns
+gmi set --ignore-tags-regex-local ""
+
+# View current settings
+gmi set
+```
+
 **`Ignore tags (remote)`** can be used to specify a list of tags (labels) which should not be synced from remote (GMail) to local. By default the [`CATEGORY_*` type](https://developers.google.com/gmail/api/guides/labels) labels which are mapped to the Personal/Promotions/etc tabs in the GMail interface are ignored. You can specify that no label should ignored by doing: `gmi set --ignore-tags-remote ""`. *Note:* This setting expects [_*un*translated_ tags](#translation-between-labels-and-tags).
   
   *Important*: See note below on [changing this setting after initial sync](#changing-ignored-tags-and-translation-after-initial-sync).
@@ -202,7 +228,7 @@ Before changing either setting make sure you are fully synchronized. After chang
 
 When changing the opposite setting: `--ignore-tags-local`, do a full push (dry-run first): `gmi push -f --dry-run`.
 
-The same goes for the options `--replace-slash-with-dot` and `--local-trash-tag`. I prefer to do `gmi pull -f --dry-run` after changing this option. This will overwrite the local tags with the remote labels.
+The same goes for the options `--ignore-tags-regex-local`, `--replace-slash-with-dot` and `--local-trash-tag`. I prefer to do `gmi pull -f --dry-run` after changing this option. This will overwrite the local tags with the remote labels.
 
 
 # Translation between labels and tags
diff --git a/lieer/gmailieer.py b/lieer/gmailieer.py
index 8430cfb..742615f 100755
--- a/lieer/gmailieer.py
+++ b/lieer/gmailieer.py
@@ -367,6 +367,13 @@ def main(self):
             help="Set custom tags to ignore when syncing from local to remote (comma-separated, after translations). Important: see the manual.",
         )
 
+        parser_set.add_argument(
+            "--ignore-tags-regex-local",
+            type=str,
+            default=None,
+            help="Set regex patterns for tags to ignore when syncing from local to remote (comma-separated, case-sensitive, uses Python regex with search matching). A tag is ignored if it matches ANY pattern. Important: see the manual.",
+        )
+
         parser_set.add_argument(
             "--ignore-tags-remote",
             type=str,
@@ -1134,6 +1141,9 @@ def set(self, args):
         if args.ignore_tags_local is not None:
             self.local.config.set_ignore_tags(args.ignore_tags_local)
 
+        if args.ignore_tags_regex_local is not None:
+            self.local.config.set_ignore_tags_regex(args.ignore_tags_regex_local)
+
         if args.ignore_tags_remote is not None:
             self.local.config.set_ignore_remote_labels(args.ignore_tags_remote)
 
@@ -1159,6 +1169,7 @@ def set(self, args):
         print("Ignore empty history ......:", self.local.config.ignore_empty_history)
         print("Replace . with / ..........:", self.local.config.replace_slash_with_dot)
         print("Ignore tags (local) .......:", self.local.config.ignore_tags)
+        print("Ignore tags regex (local) .:", self.local.config.ignore_tags_regex)
         print("Ignore labels (remote) ....:", self.local.config.ignore_remote_labels)
         print("Trash tag (local) .........:", self.local.config.local_trash_tag)
         print(
diff --git a/lieer/local.py b/lieer/local.py
index a9e5f79..27743dc 100644
--- a/lieer/local.py
+++ b/lieer/local.py
@@ -19,7 +19,9 @@
 import fcntl
 import json
 import os
+import re
 import shutil
+import sys
 import tempfile
 from pathlib import Path
 
@@ -113,6 +115,27 @@ def update_translation_list_with_overlay(self, translation_list_overlay):
             self.translate_labels[remote] = local
             self.labels_translate[local] = remote
 
+    def matches_ignore_regex(self, tag):
+        """
+        Check if a tag matches any of the ignore regex patterns.
+
+        Args:
+            tag: Tag string to check
+
+        Returns:
+            bool: True if tag matches any regex pattern
+        """
+        for regex in self.config._compiled_ignore_regex:
+            try:
+                if regex.search(tag):
+                    return True
+            except Exception as e:
+                print(
+                    f"Warning: Error matching regex pattern {regex.pattern}: {e}",
+                    file=sys.stderr,
+                )
+        return False
+
     class RepositoryException(Exception):
         pass
 
@@ -123,11 +146,40 @@ class Config:
         drop_non_existing_label = False
         ignore_empty_history = False
         ignore_tags = None
+        ignore_tags_regex = None
         ignore_remote_labels = None
         remove_local_messages = True
         file_extension = None
         local_trash_tag = "trash"
         translation_list_overlay = None
+        _compiled_ignore_regex = None
+
+        def _compile_regex_patterns(self, patterns):
+            """
+            Compile regex patterns and return valid patterns and compiled objects.
+            Invalid patterns generate warnings but are skipped.
+
+            Args:
+                patterns: Iterable of regex pattern strings
+
+            Returns:
+                Tuple of (valid_patterns, compiled_patterns)
+                - valid_patterns: List of valid pattern strings
+                - compiled_patterns: Tuple of compiled regex objects
+            """
+            valid_patterns = []
+            compiled_patterns = []
+            for pattern in patterns:
+                try:
+                    compiled = re.compile(pattern)
+                    valid_patterns.append(pattern)
+                    compiled_patterns.append(compiled)
+                except re.error as e:
+                    print(
+                        f"Warning: Invalid regex pattern '{pattern}': {e}",
+                        file=sys.stderr,
+                    )
+            return valid_patterns, tuple(compiled_patterns)
 
         def __init__(self, config_f):
             self.config_f = config_f
@@ -151,6 +203,15 @@ def __init__(self, config_f):
             self.ignore_empty_history = self.json.get("ignore_empty_history", False)
             self.remove_local_messages = self.json.get("remove_local_messages", True)
             self.ignore_tags = set(self.json.get("ignore_tags", []))
+
+            # Load regex patterns from config and compile them
+            regex_patterns = self.json.get("ignore_tags_regex", [])
+            valid_patterns, compiled_patterns = self._compile_regex_patterns(
+                regex_patterns
+            )
+            self.ignore_tags_regex = set(valid_patterns)
+            self._compiled_ignore_regex = compiled_patterns
+
             self.ignore_remote_labels = set(
                 self.json.get("ignore_remote_labels", Remote.DEFAULT_IGNORE_LABELS)
             )
@@ -169,6 +230,7 @@ def write(self):
             self.json["drop_non_existing_label"] = self.drop_non_existing_label
             self.json["ignore_empty_history"] = self.ignore_empty_history
             self.json["ignore_tags"] = list(self.ignore_tags)
+            self.json["ignore_tags_regex"] = list(self.ignore_tags_regex)
             self.json["ignore_remote_labels"] = list(self.ignore_remote_labels)
             self.json["remove_local_messages"] = self.remove_local_messages
             self.json["file_extension"] = self.file_extension
@@ -216,6 +278,27 @@ def set_ignore_tags(self, t):
 
             self.write()
 
+        def set_ignore_tags_regex(self, t):
+            """
+            Set regex patterns for ignoring local tags.
+
+            Args:
+                t: Comma-separated string of regex patterns
+            """
+            if len(t.strip()) == 0:
+                self.ignore_tags_regex = set()
+                self._compiled_ignore_regex = ()
+            else:
+                patterns = [p.strip() for p in t.split(",")]
+                # Compile patterns and collect only the valid ones
+                valid_patterns, compiled_patterns = self._compile_regex_patterns(
+                    patterns
+                )
+                self.ignore_tags_regex = set(valid_patterns)
+                self._compiled_ignore_regex = compiled_patterns
+
+            self.write()
+
         def set_ignore_remote_labels(self, t):
             if len(t.strip()) == 0:
                 self.ignore_remote_labels = set()
@@ -714,8 +797,12 @@ def update_tags(self, m, fname, db):
         else:
             # message is already in db, set local tags to match remote tags
             otags = nmsg.tags
+            # Collect all ignored tags (exact match + regex match)
             igntags = otags & self.ignore_labels
-            otags = otags - self.ignore_labels  # remove ignored tags while checking
+            regex_ignored = {tag for tag in otags if self.matches_ignore_regex(tag)}
+            igntags = igntags | regex_ignored
+            # Remove all ignored tags for comparison
+            otags = otags - igntags
             if otags != set(labels):
                 labels.extend(igntags)  # add back local ignored tags before adding
                 if not self.dry_run:
diff --git a/lieer/remote.py b/lieer/remote.py
index 57ee057..2ed7c93 100644
--- a/lieer/remote.py
+++ b/lieer/remote.py
@@ -651,6 +651,10 @@ def update(self, gmsg, nmsg, last_hist, force):
 
         # remove special notmuch tags
         tags = tags - self.gmailieer.local.ignore_labels
+        # remove tags matching regex patterns
+        tags = {
+            tag for tag in tags if not self.gmailieer.local.matches_ignore_regex(tag)
+        }
 
         add = list((tags - labels) - self.read_only_tags)
         rem = list((labels - tags) - self.read_only_tags)
diff --git a/tests/test_ignore_tags_regex.py b/tests/test_ignore_tags_regex.py
new file mode 100644
index 0000000..320e6de
--- /dev/null
+++ b/tests/test_ignore_tags_regex.py
@@ -0,0 +1,139 @@
+"""
+Tests for ignore_tags_regex_local functionality
+"""
+
+import json
+import os
+import tempfile
+from types import MethodType
+
+import pytest
+
+from lieer.local import Local
+
+
+@pytest.fixture
+def temp_config_file():
+    """Create a temporary config file for testing"""
+    with tempfile.TemporaryDirectory() as tmpdir:
+        config_file = os.path.join(tmpdir, ".gmailieer.json")
+        yield config_file
+
+
+@pytest.fixture
+def fake_local(temp_config_file):
+    """Create a fake Local instance for testing regex matching"""
+
+    class FakeLocal:
+        pass
+
+    def create_with_patterns(patterns):
+        test_config = {"account": "test@example.com", "ignore_tags_regex": patterns}
+        with open(temp_config_file, "w") as f:
+            json.dump(test_config, f)
+
+        fake = FakeLocal()
+        fake.config = Local.Config(temp_config_file)
+        fake.matches_ignore_regex = MethodType(Local.matches_ignore_regex, fake)
+        return fake
+
+    return create_with_patterns
+
+
+def test_regex_patterns_load_and_compile(temp_config_file):
+    """Test that regex patterns load from config and compile correctly"""
+    test_config = {
+        "account": "test@example.com",
+        "ignore_tags_regex": ["^draft-.*", "temp-.*", "work/.*"],
+    }
+
+    with open(temp_config_file, "w") as f:
+        json.dump(test_config, f)
+
+    config = Local.Config(temp_config_file)
+
+    assert len(config.ignore_tags_regex) == 3
+    assert len(config._compiled_ignore_regex) == 3
+
+
+def test_invalid_regex_patterns_skipped(temp_config_file):
+    """Test that invalid regex patterns generate warnings but don't fail"""
+    test_config = {
+        "account": "test@example.com",
+        "ignore_tags_regex": ["^draft-.*", "[invalid(", "valid-pattern"],
+    }
+
+    with open(temp_config_file, "w") as f:
+        json.dump(test_config, f)
+
+    config = Local.Config(temp_config_file)
+
+    # Only valid patterns should be compiled
+    assert len(config._compiled_ignore_regex) == 2
+    assert "^draft-.*" in config.ignore_tags_regex
+    assert "valid-pattern" in config.ignore_tags_regex
+    assert "[invalid(" not in config.ignore_tags_regex
+
+
+def test_regex_matching_patterns(fake_local):
+    """Test matching various regex patterns (prefix, suffix, contains)"""
+    local = fake_local(["^draft-.*", ".*-temp$", "work/.*"])
+
+    # Prefix match
+    assert local.matches_ignore_regex("draft-v1")
+    assert not local.matches_ignore_regex("my-draft")
+
+    # Suffix match
+    assert local.matches_ignore_regex("file-temp")
+    assert not local.matches_ignore_regex("temp-file")
+
+    # Contains match
+    assert local.matches_ignore_regex("work/project")
+    assert not local.matches_ignore_regex("homework")
+
+    # No match
+    assert not local.matches_ignore_regex("normal-tag")
+
+
+def test_regex_matching_case_sensitive(fake_local):
+    """Test that regex matching is case-sensitive"""
+    local = fake_local(["^draft-.*"])
+
+    assert local.matches_ignore_regex("draft-v1")
+    assert not local.matches_ignore_regex("Draft-v1")
+
+
+def test_setter_method_persistence(temp_config_file):
+    """Test that setter method works and persists to config"""
+    test_config = {"account": "test@example.com"}
+
+    with open(temp_config_file, "w") as f:
+        json.dump(test_config, f)
+
+    config = Local.Config(temp_config_file)
+    config.set_ignore_tags_regex("^draft-.*,temp-.*")
+
+    assert len(config.ignore_tags_regex) == 2
+    assert len(config._compiled_ignore_regex) == 2
+
+    # Reload to verify persistence
+    config2 = Local.Config(temp_config_file)
+    assert len(config2.ignore_tags_regex) == 2
+    assert "^draft-.*" in config2.ignore_tags_regex
+
+
+def test_setter_method_clears_patterns(temp_config_file):
+    """Test that empty string clears patterns"""
+    test_config = {
+        "account": "test@example.com",
+        "ignore_tags_regex": ["^draft-.*"],
+    }
+
+    with open(temp_config_file, "w") as f:
+        json.dump(test_config, f)
+
+    config = Local.Config(temp_config_file)
+    config.set_ignore_tags_regex("")
+
+    assert len(config.ignore_tags_regex) == 0
+    assert len(config._compiled_ignore_regex) == 0