diff --git a/index.js b/index.js
index c0638e08..05d66328 100644
--- a/index.js
+++ b/index.js
@@ -171,6 +171,12 @@ function compression (options) {
         return
       }
 
+      // response is partial content
+      if (res.statusCode === 206) {
+        nocompress('partial content')
+        return
+      }
+
       // vary
       vary(res, 'Accept-Encoding')
 
diff --git a/test/compression.js b/test/compression.js
index 8107def0..77de019d 100644
--- a/test/compression.js
+++ b/test/compression.js
@@ -67,6 +67,25 @@ describe('compression()', function () {
       .expect(200, 'hello, world', done)
   })
 
+  it('should skip partial content responses', function (done) {
+    var server = createServer({ threshold: 0 }, function (req, res) {
+      res.statusCode = 206
+      res.setHeader('Content-Type', 'text/plain')
+      res.setHeader('Content-Range', 'bytes 0-4/12')
+      res.setHeader('Content-Length', '5')
+      res.end('hello')
+    })
+
+    request(server)
+      .get('/')
+      .set('Accept-Encoding', 'gzip')
+      .set('Range', 'bytes=0-4')
+      .expect(shouldNotHaveHeader('Content-Encoding'))
+      .expect('Content-Range', 'bytes 0-4/12')
+      .expect('Content-Length', '5')
+      .expect(206, 'hello', done)
+  })
+
   it('should set Vary', function (done) {
     var server = createServer({ threshold: 0 }, function (req, res) {
       res.setHeader('Content-Type', 'text/plain')