Create dapp with Vyper and use python to interact with Vyper dapp ? Make sense ? :)
https://ethereum.org/en/developers/tutorials/a-developers-guide-to-ethereum-part-one/ https://ethereum.org/en/developers/docs/programming-languages/python/ https://snakecharmers.ethereum.org/a-developers-guide-to-ethereum-pt-2/ https://snakecharmers.ethereum.org/
https://web3py.readthedocs.io/en/stable/quickstart.html
Note: “Ethereum node” and “Ethereum client” are used interchangeably. In either case, it refers to the software that a participant in the Ethereum network runs. This software can read block data, receive updates when new blocks are added to the chain ("mined"), broadcast new transactions, and more. source: "https://ethereum.org/en/developers/tutorials/a-developers-guide-to-ethereum-part-one/"
Development Server for Ethereum based apps ?