data_compound.csv

cid,smiles,bioactivity,type,value (nM)
118159176,C[C@@H](C(=O)N1CCC2=C(C1)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)OC,Active,IC50,8300
118159176,C[C@@H](C(=O)N1CCC2=C(C1)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)OC,Active,IC50,8300
118159176,C[C@@H](C(=O)N1CCC2=C(C1)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)OC,Active,IC50,8300
127024762,C[C@@H](CO)NC1=NC2=CC=CC=C2N=C1N3CCN(CC3)CC4=C(C=CC(=C4)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,1570
127024157,C[C@@H]1C[C@H]1NC2=NC3=CN=NC=C3N=C2N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,145
118159182,C[C@H](C(=O)N1CCC2=C(C1)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)OC,Active,IC50,6600
118159182,C[C@H](C(=O)N1CCC2=C(C1)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)OC,Active,IC50,6600
118159182,C[C@H](C(=O)N1CCC2=C(C1)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)OC,Active,IC50,6600
155525744,C[C@H](CO)NC1=NC2=CC=CC=C2N=C1N3CCN(CC3)CC4=C(C=CC(=C4)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,1570
90037932,C1CC(C1)NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)C(=O)C5=CC=C(C=C5)Cl,Active,IC50,300
90037932,C1CC(C1)NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)C(=O)C5=CC=C(C=C5)Cl,Active,IC50,300
73295084,C1CC(C1)NC2=NC3=C(C=CN=C3)N=C2N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Active,IC50,14
73295084,C1CC(C1)NC2=NC3=C(C=CN=C3)N=C2N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Active,IC50,14
127024247,C1CC1CNC2=NC3=CC=CC=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,3160
127024247,C1CC1CNC2=NC3=CC=CC=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,3160
127024694,C1CC1NC2=NC3=C(C(=NC=C3)C#N)N=C2N4CCN(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,66
127024694,C1CC1NC2=NC3=C(C(=NC=C3)C#N)N=C2N4CCN(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,66
127024707,C1CC1NC2=NC3=C(C(=NC=C3)C(=O)N4CCOCC4)N=C2N5CCC(CC5)[C@@H](C6=C(C=C(C=C6)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,6
127024707,C1CC1NC2=NC3=C(C(=NC=C3)C(=O)N4CCOCC4)N=C2N5CCC(CC5)[C@@H](C6=C(C=C(C=C6)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,6
127024129,C1CC1NC2=NC3=C(C(=NC=C3)C(=O)N4CCOCC4)N=C2N5CCC(CC5)[C@H](C6=C(C=C(C=C6)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,7
127024129,C1CC1NC2=NC3=C(C(=NC=C3)C(=O)N4CCOCC4)N=C2N5CCC(CC5)[C@H](C6=C(C=C(C=C6)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,7
127024297,C1CC1NC2=NC3=C(C=C(C=C3)Br)N=C2N4CCC(CC4)OC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,1430
127024297,C1CC1NC2=NC3=C(C=C(C=C3)Br)N=C2N4CCC(CC4)OC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,1430
127024219,C1CC1NC2=NC3=C(C=C(C=C3)Br)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,4820
127024219,C1CC1NC2=NC3=C(C=C(C=C3)Br)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,4820
127024606,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCC(CC4)C(C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,24
127024606,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCC(CC4)C(C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,24
127024736,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCC(CC4)C(C5=C(C=CC(=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,75
127024736,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCC(CC4)C(C5=C(C=CC(=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,75
127024463,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCC(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,64
127024463,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCC(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,64
90038741,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCC(CC4)CN5C=C(C=CC5=O)Cl,Active,IC50,930
90038741,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCC(CC4)CN5C=C(C=CC5=O)Cl,Active,IC50,930
127024693,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCC(CC4)OC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,90
127024693,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCC(CC4)OC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,90
90038545,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl,Active,IC50,250
90038545,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl,Active,IC50,250
127024688,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,380
127024688,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,380
127024285,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=C(C=C(C=C5)C(F)(F)F)Cl.C(=O)(C(F)(F)F)O,Active,IC50,1300
127024285,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=C(C=C(C=C5)C(F)(F)F)Cl.C(=O)(C(F)(F)F)O,Active,IC50,1300
127024598,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=C(C=CC(=C5)C(F)(F)F)Cl.C(=O)(C(F)(F)F)O,Active,IC50,1360
127024598,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=C(C=CC(=C5)C(F)(F)F)Cl.C(=O)(C(F)(F)F)O,Active,IC50,1360
90037349,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=CC(=CC=C5)Cl,Active,IC50,5620
90037349,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=CC(=CC=C5)Cl,Active,IC50,5620
127024602,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=CC=C(C=C5)Cl.C(=O)(C(F)(F)F)O,Active,IC50,570
127024602,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=CC=C(C=C5)Cl.C(=O)(C(F)(F)F)O,Active,IC50,570
127024547,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=CC=C(C=C5)OC(F)(F)F.C(=O)(C(F)(F)F)O,Active,IC50,4290
127024547,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=CC=C(C=C5)OC(F)(F)F.C(=O)(C(F)(F)F)O,Active,IC50,4290
127024597,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=CC=C(S5)Br.C(=O)(C(F)(F)F)O,Active,IC50,420
127024597,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=CC=C(S5)Br.C(=O)(C(F)(F)F)O,Active,IC50,420
127024687,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=CC=CC(=C5)C#N.C(=O)(C(F)(F)F)O,Active,IC50,2540
127024687,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=CC=CC(=C5)C#N.C(=O)(C(F)(F)F)O,Active,IC50,2540
90037835,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=CC=CC=C5Br,Active,IC50,1850
90037835,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=CC=CC=C5Br,Active,IC50,1850
127024265,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=CC=CC=C5C#N.C(=O)(C(F)(F)F)O,Active,IC50,4340
127024265,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=CC=CC=C5C#N.C(=O)(C(F)(F)F)O,Active,IC50,4340
127024419,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=CC=CC=C5F.C(=O)(C(F)(F)F)O,Active,IC50,4590
127024419,C1CC1NC2=NC3=C(C=C(C=C3)C#N)N=C2N4CCN(CC4)S(=O)(=O)C5=CC=CC=C5F.C(=O)(C(F)(F)F)O,Active,IC50,4590
127024559,C1CC1NC2=NC3=C(C=C(C=C3)F)N=C2N4CCC(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,72
127024559,C1CC1NC2=NC3=C(C=C(C=C3)F)N=C2N4CCC(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,72
90038663,C1CC1NC2=NC3=C(C=C(C=C3)F)N=C2N4CCN(CC4)S(=O)(=O)C5=CC=CC=C5,Active,IC50,9440
90038663,C1CC1NC2=NC3=C(C=C(C=C3)F)N=C2N4CCN(CC4)S(=O)(=O)C5=CC=CC=C5,Active,IC50,9440
90038494,C1CC1NC2=NC3=C(C=C(N=C3)C#N)N=C2N4CCC(CC4)[C@@H](C5=C(C=C(C=C5)F)F)F,Active,IC50,45
90038494,C1CC1NC2=NC3=C(C=C(N=C3)C#N)N=C2N4CCC(CC4)[C@@H](C5=C(C=C(C=C5)F)F)F,Active,IC50,45
118308533,C1CC1NC2=NC3=C(C=C(N=C3)C#N)N=C2N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F,Active,IC50,24
118308533,C1CC1NC2=NC3=C(C=C(N=C3)C#N)N=C2N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F,Active,IC50,24
127024248,C1CC1NC2=NC3=C(C=CC(=C3)Br)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,2340
127024248,C1CC1NC2=NC3=C(C=CC(=C3)Br)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,2340
127024288,C1CC1NC2=NC3=C(C=CC(=C3)C#N)N=C2N4CCC(CC4)C(C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,29
127024288,C1CC1NC2=NC3=C(C=CC(=C3)C#N)N=C2N4CCC(CC4)C(C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,29
127024282,C1CC1NC2=NC3=C(C=CC(=C3)C#N)N=C2N4CCN(CC4)C(=O)C5=CC=C(C=C5)Cl.C(=O)(C(F)(F)F)O,Active,IC50,340
127024282,C1CC1NC2=NC3=C(C=CC(=C3)C#N)N=C2N4CCN(CC4)C(=O)C5=CC=C(C=C5)Cl.C(=O)(C(F)(F)F)O,Active,IC50,340
127024384,C1CC1NC2=NC3=C(C=CC=C3Br)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,1640
127024384,C1CC1NC2=NC3=C(C=CC=C3Br)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,1640
127024264,C1CC1NC2=NC3=C(C=CC=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl)C#N.C(=O)(C(F)(F)F)O,Active,IC50,1490
127024264,C1CC1NC2=NC3=C(C=CC=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl)C#N.C(=O)(C(F)(F)F)O,Active,IC50,1490
127024823,C1CC1NC2=NC3=C(C=CN=C3)N=C2N4CCC(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,27
127024823,C1CC1NC2=NC3=C(C=CN=C3)N=C2N4CCC(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,27
127024451,C1CC1NC2=NC3=C(C=CN=C3)N=C2N4CCC(CC4)OC5=C(C=C(C=C5)O)F.C(=O)(C(F)(F)F)O,Active,IC50,54
127024451,C1CC1NC2=NC3=C(C=CN=C3)N=C2N4CCC(CC4)OC5=C(C=C(C=C5)O)F.C(=O)(C(F)(F)F)O,Active,IC50,54
127024449,C1CC1NC2=NC3=C(C=CN=C3)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,56
127024449,C1CC1NC2=NC3=C(C=CN=C3)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,56
127024455,C1CC1NC2=NC3=C(C=CN=C3)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,140
127024455,C1CC1NC2=NC3=C(C=CN=C3)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,140
90038062,C1CC1NC2=NC3=C(C=NC(=C3)C#N)N=C2N4CCC(CC4)[C@@H](C5=C(C=C(C=C5)F)F)F,Active,IC50,11
90038062,C1CC1NC2=NC3=C(C=NC(=C3)C#N)N=C2N4CCC(CC4)[C@@H](C5=C(C=C(C=C5)F)F)F,Active,IC50,11
90039456,C1CC1NC2=NC3=C(C=NC(=C3)C#N)N=C2N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F,Active,IC50,17
127024834,C1CC1NC2=NC3=C(C=NC(=C3)C#N)N=C2N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,17
90038234,C1CC1NC2=NC3=C(C=NC(=C3)C#N)N=C2N4CCC(CC4)CC5=C(C=C(C=C5)F)F,Active,IC50,15
90038234,C1CC1NC2=NC3=C(C=NC(=C3)C#N)N=C2N4CCC(CC4)CC5=C(C=C(C=C5)F)F,Active,IC50,15
127024159,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)[C@@H](C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,24
127024159,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)[C@@H](C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,24
127024706,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(C(=CC=C5)F)Cl.Cl,Active,IC50,2800
127024706,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(C(=CC=C5)F)Cl.Cl,Active,IC50,2800
127024775,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(C=C(C=C5F)Cl)F.C(=O)(C(F)(F)F)O,Active,IC50,200
127024775,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(C=C(C=C5F)Cl)F.C(=O)(C(F)(F)F)O,Active,IC50,200
127024552,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(C=CC(=C5)C#N)F.C(=O)(C(F)(F)F)O,Active,IC50,69
127024552,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(C=CC(=C5)C#N)F.C(=O)(C(F)(F)F)O,Active,IC50,69
127024776,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(C=CC(=C5)Cl)F.C(=O)(C(F)(F)F)O,Active,IC50,35
127024776,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(C=CC(=C5)Cl)F.C(=O)(C(F)(F)F)O,Active,IC50,35
127024705,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(C=CC(=C5)F)Cl.C(=O)(C(F)(F)F)O,Active,IC50,62
127024705,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(C=CC(=C5)F)Cl.C(=O)(C(F)(F)F)O,Active,IC50,62
127024824,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(C=CC(=C5F)F)Cl.C(=O)(C(F)(F)F)O,Active,IC50,3900
127024824,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(C=CC(=C5F)F)Cl.C(=O)(C(F)(F)F)O,Active,IC50,3900
90038404,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(C=CC=C5Cl)F,Active,IC50,4900
90038404,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(C=CC=C5Cl)F,Active,IC50,4900
127024837,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(C=CC=C5F)F.C(=O)(C(F)(F)F)O,Active,IC50,2180
127024837,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(C=CC=C5F)F.C(=O)(C(F)(F)F)O,Active,IC50,2180
127024777,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(N=CC=C5)Br.C(=O)(C(F)(F)F)O,Active,IC50,2740
127024777,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=C(N=CC=C5)Br.C(=O)(C(F)(F)F)O,Active,IC50,2740
127024836,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=CC(=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,8390
127024836,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=CC(=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,8390
90038923,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=CC=CC(=C5)C#N,Active,IC50,7210
127024128,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=CC=CC(=C5)C#N.C(=O)(C(F)(F)F)O,Active,IC50,7210
127024592,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=CC=CC=C5Br.C(=O)(C(F)(F)F)O,Active,IC50,78
127024592,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=CC=CC=C5Br.C(=O)(C(F)(F)F)O,Active,IC50,78
127024704,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=CC=CC=C5Cl.C(=O)(C(F)(F)F)O,Active,IC50,67
127024704,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=CC=CC=C5Cl.C(=O)(C(F)(F)F)O,Active,IC50,67
127024825,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=CC=CS5.C(=O)(C(F)(F)F)O,Active,IC50,6750
127024825,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=CC=CS5.C(=O)(C(F)(F)F)O,Active,IC50,6750
127024126,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=CSC(=C5)Cl.Cl,Active,IC50,4810
127024126,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=CSC(=C5)Cl.Cl,Active,IC50,4810
90038340,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=CSC=C5.C(=O)(C(F)(F)F)O,Active,IC50,2290
90038340,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(=O)C5=CSC=C5.C(=O)(C(F)(F)F)O,Active,IC50,2290
90038632,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(C5=C(C=C(C=C5)F)F)(F)F,Active,IC50,16
90038632,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(C5=C(C=C(C=C5)F)F)(F)F,Active,IC50,16
118308672,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(C5=C(C=CC(=C5)Cl)F)(F)F,Active,IC50,46
118308672,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(C5=C(C=CC(=C5)Cl)F)(F)F,Active,IC50,46
118308594,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(C5=C(C=CC(=C5)F)F)F,Active,IC50,20
118308594,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)C(C5=C(C=CC(=C5)F)F)F,Active,IC50,20
155555998,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,19
155518204,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)OC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,1100
127024774,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)OC5=C(C=C(C=C5F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,170
127024774,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)OC5=C(C=C(C=C5F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,170
127024773,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)OC5=C(C=CC(=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,1100
90038032,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)OC5=CC=C(C=C5)C#N,Active,IC50,1940
90038032,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)OC5=CC=C(C=C5)C#N,Active,IC50,1940
127024465,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)OC5=CC=C(C=C5)Cl.C(=O)(C(F)(F)F)O,Active,IC50,310
127024465,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)OC5=CC=C(C=C5)Cl.C(=O)(C(F)(F)F)O,Active,IC50,310
90038583,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)OC5=CC=CC=C5C#N,Active,IC50,2883
155567731,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)OC5=CC=CC=C5C#N.C(=O)(C(F)(F)F)O,Active,IC50,2883
127024464,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)OC5=CC=CC=C5Cl.C(=O)(C(F)(F)F)O,Active,IC50,1510
127024464,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCC(CC4)OC5=CC=CC=C5Cl.C(=O)(C(F)(F)F)O,Active,IC50,1510
127024453,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCN(CC4)C(=O)C5=CC=C(C=C5)C(F)F.C(=O)(C(F)(F)F)O,Active,IC50,2650
127024453,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCN(CC4)C(=O)C5=CC=C(C=C5)C(F)F.C(=O)(C(F)(F)F)O,Active,IC50,2650
155536861,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCN(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,21
127024345,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,32
127024345,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,32
127024341,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)F.C(=O)(C(F)(F)F)O,Active,IC50,29
127024341,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)F.C(=O)(C(F)(F)F)O,Active,IC50,29
127024454,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)OC(F)F.C(=O)(C(F)(F)F)O,Active,IC50,270
127024454,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)OC(F)F.C(=O)(C(F)(F)F)O,Active,IC50,270
127024728,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,120
127024728,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,120
127024284,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCN(CC4)CC5=CC(=C(C=C5F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,50
127024284,C1CC1NC2=NC3=C(C=NC=C3)N=C2N4CCN(CC4)CC5=CC(=C(C=C5F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,50
127024149,C1CC1NC2=NC3=C(C=NC=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,62
155534644,C1CC1NC2=NC3=C(C=NC=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)F)F)Cl.C(=O)(C(F)(F)F)O,Active,IC50,62
118308530,C1CC1NC2=NC3=C(N=CC=C3)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl,Active,IC50,1130
118308530,C1CC1NC2=NC3=C(N=CC=C3)N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl,Active,IC50,1130
127024737,C1CC1NC2=NC3=CC(=C(C=C3N=C2N4CCC(CC4)CC5=C(C=C(C=C5)F)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,140
127024737,C1CC1NC2=NC3=CC(=C(C=C3N=C2N4CCC(CC4)CC5=C(C=C(C=C5)F)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,140
127024418,C1CC1NC2=NC3=CC(=C(C=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl)F)F.C(=O)(C(F)(F)F)O,Active,IC50,800
127024418,C1CC1NC2=NC3=CC(=C(C=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl)F)F.C(=O)(C(F)(F)F)O,Active,IC50,800
127024600,C1CC1NC2=NC3=CC(=C(C=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)F)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,1470
127024600,C1CC1NC2=NC3=CC(=C(C=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)F)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,1470
127024110,C1CC1NC2=NC3=CC(=NC=C3N=C2N4CCC(CC4)[C@@H](C5=C(C=C(C=C5)F)F)F)Cl.C(=O)(C(F)(F)F)O,Active,IC50,29
127024110,C1CC1NC2=NC3=CC(=NC=C3N=C2N4CCC(CC4)[C@@H](C5=C(C=C(C=C5)F)F)F)Cl.C(=O)(C(F)(F)F)O,Active,IC50,29
127024593,C1CC1NC2=NC3=CC(=NC=C3N=C2N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F)C(=O)N6CCC6F,Active,IC50,26
127024593,C1CC1NC2=NC3=CC(=NC=C3N=C2N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F)C(=O)N6CCC6F,Active,IC50,26
127024346,C1CC1NC2=NC3=CC(=NC=C3N=C2N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F)Cl.C(=O)(C(F)(F)F)O,Active,IC50,15
127024346,C1CC1NC2=NC3=CC(=NC=C3N=C2N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F)Cl.C(=O)(C(F)(F)F)O,Active,IC50,15
90038387,C1CC1NC2=NC3=CC(=NC=C3N=C2N4CCC(CC4)C(=O)C5=C(C=CC(=C5)C#N)Cl)Cl,Active,IC50,89
90038387,C1CC1NC2=NC3=CC(=NC=C3N=C2N4CCC(CC4)C(=O)C5=C(C=CC(=C5)C#N)Cl)Cl,Active,IC50,89
127024158,C1CC1NC2=NC3=CC(=NC=C3N=C2N4CCC(CC4)C(C5=C(C=C(C=C5)F)F)F)Br.C(=O)(C(F)(F)F)O,Active,IC50,29
127024158,C1CC1NC2=NC3=CC(=NC=C3N=C2N4CCC(CC4)C(C5=C(C=C(C=C5)F)F)F)Br.C(=O)(C(F)(F)F)O,Active,IC50,29
90037926,C1CC1NC2=NC3=CC(=NC=C3N=C2N4CCC(CC4)CC5=C(C=C(C=C5)F)F)Cl,Active,IC50,31
90037926,C1CC1NC2=NC3=CC(=NC=C3N=C2N4CCC(CC4)CC5=C(C=C(C=C5)F)F)Cl,Active,IC50,31
127024222,C1CC1NC2=NC3=CC=CC(=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl)C#N.C(=O)(C(F)(F)F)O,Active,IC50,650
127024222,C1CC1NC2=NC3=CC=CC(=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl)C#N.C(=O)(C(F)(F)F)O,Active,IC50,650
127024832,C1CC1NC2=NC3=CC=CC=C3N=C2N4CCC(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,19
127024203,C1CC1NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)C(=O)C5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,6640
127024203,C1CC1NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)C(=O)C5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,6640
127024393,C1CC1NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)C(=O)C5=CC(=C(C=C5)F)Br.C(=O)(C(F)(F)F)O,Active,IC50,4780
127024393,C1CC1NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)C(=O)C5=CC(=C(C=C5)F)Br.C(=O)(C(F)(F)F)O,Active,IC50,4780
127024391,C1CC1NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,2160
127024391,C1CC1NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,2160
127024348,C1CC1NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,4580
127024348,C1CC1NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,4580
127024198,C1CC1NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)CC5=C(SC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,6030
127024198,C1CC1NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)CC5=C(SC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,6030
90038419,C1CC1NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)CC5=COC6=CC=CC=C65,Active,IC50,3960
90038419,C1CC1NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)CC5=COC6=CC=CC=C65,Active,IC50,3960
90037553,C1CC1NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)S(=O)(=O)C5=CC=CC=C5,Active,IC50,5660
90037553,C1CC1NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)S(=O)(=O)C5=CC=CC=C5,Active,IC50,5660
127024594,C1CC1NC2=NC3=CN=NC=C3N=C2N4CCC(CC4)[C@@H](C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,26
127024594,C1CC1NC2=NC3=CN=NC=C3N=C2N4CCC(CC4)[C@@H](C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,26
127024639,C1CC1NC2=NC3=CN=NC=C3N=C2N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,22
127024639,C1CC1NC2=NC3=CN=NC=C3N=C2N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,22
127024501,C1CC1NC2=NC3=CN=NC=C3N=C2N4CCC(CC4)OC5=C(C=C(C=C5)C#N)F.C(=O)(C(F)(F)F)O,Active,IC50,90
127024501,C1CC1NC2=NC3=CN=NC=C3N=C2N4CCC(CC4)OC5=C(C=C(C=C5)C#N)F.C(=O)(C(F)(F)F)O,Active,IC50,90
90038509,C1CC1NC2=NC3=CN=NC=C3N=C2N4CCC(CC4)OC5=C(C=C(C=C5)Cl)F.C(=O)(C(F)(F)F)O,Active,IC50,30
90038509,C1CC1NC2=NC3=CN=NC=C3N=C2N4CCC(CC4)OC5=C(C=C(C=C5)Cl)F.C(=O)(C(F)(F)F)O,Active,IC50,30
127024293,C1CC1NC2=NC3=CN=NC=C3N=C2N4CCC(CC4)OC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,18
127024293,C1CC1NC2=NC3=CN=NC=C3N=C2N4CCC(CC4)OC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,18
127024759,C1CC1NC2=NC3=CN=NC=C3N=C2N4CCN(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,260
127024759,C1CC1NC2=NC3=CN=NC=C3N=C2N4CCN(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,260
127024462,C1CCC(C1)NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)C(=O)C5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,6150
127024462,C1CCC(C1)NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)C(=O)C5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,6150
9966125,C1CN(C(=S)N1)C(=S)NC(=O)C2=C(C=C(C=C2)F)F,Active,IC50,110
9966125,C1CN(C(=S)N1)C(=S)NC(=O)C2=C(C=C(C=C2)F)F,Active,IC50,110
9966125,C1CN(C(=S)N1)C(=S)NC(=O)C2=C(C=C(C=C2)F)F,Active,IC50,170
9966125,C1CN(C(=S)N1)C(=S)NC(=O)C2=C(C=C(C=C2)F)F,Active,IC50,170
9835479,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC(=CC=C2)F,Active,IC50,2620
9835479,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC(=CC=C2)F,Active,IC50,2620
9835479,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC(=CC=C2)F,Active,IC50,3190
9835479,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC(=CC=C2)F,Active,IC50,3190
10131705,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=C(C=C2)C(F)(F)F,Active,IC50,1570
10131705,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=C(C=C2)C(F)(F)F,Active,IC50,1570
10131705,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=C(C=C2)C(F)(F)F,Active,IC50,3650
10131705,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=C(C=C2)C(F)(F)F,Active,IC50,3650
9900928,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=C(C=C2)Cl,Active,IC50,450
9900928,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=C(C=C2)Cl,Active,IC50,450
9900928,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=C(C=C2)Cl,Active,IC50,1970
9900928,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=C(C=C2)Cl,Active,IC50,1970
9965602,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=C(C=C2)F,Active,IC50,480
9965602,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=C(C=C2)F,Active,IC50,480
9965602,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=C(C=C2)F,Active,IC50,1250
9965602,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=C(C=C2)F,Active,IC50,1250
9965300,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=CS2,Active,IC50,1960
9965300,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=CS2,Active,IC50,1960
9965300,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=CS2,Active,IC50,2790
9965300,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=CS2,Active,IC50,2790
9878298,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=NO2,Active,IC50,2430
9878298,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=NO2,Active,IC50,2430
9878298,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=NO2,Active,IC50,5830
9878298,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC=NO2,Active,IC50,5830
9879918,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC3=CC=CC=C3C=C2,Active,IC50,710
9879918,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC3=CC=CC=C3C=C2,Active,IC50,710
9836813,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC3=CC=CC=C3S2,Active,IC50,260
9836813,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC3=CC=CC=C3S2,Active,IC50,260
9836813,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC3=CC=CC=C3S2,Active,IC50,4520
9836813,C1CN(C(=S)N1)C(=S)NC(=O)C2=CC3=CC=CC=C3S2,Active,IC50,4520
9835088,C1CN(C(=S)N1)C(=S)NC(=O)C2=CN=CC=C2,Active,IC50,850
9835088,C1CN(C(=S)N1)C(=S)NC(=O)C2=CN=CC=C2,Active,IC50,850
9835088,C1CN(C(=S)N1)C(=S)NC(=O)C2=CN=CC=C2,Active,IC50,6560
9835088,C1CN(C(=S)N1)C(=S)NC(=O)C2=CN=CC=C2,Active,IC50,6560
90039351,C1CN(C1)C(=O)C2=NC=C3C(=C2)N=C(C(=N3)N4CCC(CC4)[C@@H](C5=C(C=C(C=C5)F)F)F)NC6CC6,Active,IC50,23
122420746,C1CN(C1)C(=O)C2=NC=C3C(=C2)N=C(C(=N3)N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F)NC6CC6,Active,IC50,22
127024446,C1CN(C1)C(=O)C2=NC=C3C(=C2)N=C(C(=N3)N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F)NC6CC6.C(=O)(C(F)(F)F)O,Active,IC50,22
127024833,C1CN(CCC1CC2=C(C=C(C=C2)F)F)C3=NC4=C(C=CC(=C4)C#N)N=C3NC5=CN=CC=C5.C(=O)(C(F)(F)F)O,Active,IC50,390
127024833,C1CN(CCC1CC2=C(C=C(C=C2)F)F)C3=NC4=C(C=CC(=C4)C#N)N=C3NC5=CN=CC=C5.C(=O)(C(F)(F)F)O,Active,IC50,390
90038811,C1CN(CCC1CC2=C(C=C(C=C2)F)F)C3=NC4=C(C=CC(=C4)C#N)N=C3NCC(F)F,Active,IC50,71
90038811,C1CN(CCC1CC2=C(C=C(C=C2)F)F)C3=NC4=C(C=CC(=C4)C#N)N=C3NCC(F)F,Active,IC50,71
90037616,C1CN(CCC1CC2=C(C=C(C=C2)F)F)C3=NC4=C(C=NC=C4)N=C3NCC(F)F,Active,IC50,78
90037616,C1CN(CCC1CC2=C(C=C(C=C2)F)F)C3=NC4=C(C=NC=C4)N=C3NCC(F)F,Active,IC50,78
127024296,C1CN(CCC1OC2=C(C=C(C=C2)F)F)C3=NC4=C(C=CC(=C4)C#N)N=C3NCCC(F)(F)F.C(=O)(C(F)(F)F)O,Active,IC50,160
127024296,C1CN(CCC1OC2=C(C=C(C=C2)F)F)C3=NC4=C(C=CC(=C4)C#N)N=C3NCCC(F)(F)F.C(=O)(C(F)(F)F)O,Active,IC50,160
127024147,C1CN(CCN1C2=NC3=C(C=CC(=C3)C#N)N=C2NCCF)C(=O)C4=CC=C(C=C4)Cl.C(=O)(C(F)(F)F)O,Active,IC50,960
127024147,C1CN(CCN1C2=NC3=C(C=CC(=C3)C#N)N=C2NCCF)C(=O)C4=CC=C(C=C4)Cl.C(=O)(C(F)(F)F)O,Active,IC50,960
90038375,C1CN(CCN1C2=NC3=CC=CC=C3N=C2NC4=CN=CC=C4)S(=O)(=O)C5=CC=CC=C5,Active,IC50,4630
90038375,C1CN(CCN1C2=NC3=CC=CC=C3N=C2NC4=CN=CC=C4)S(=O)(=O)C5=CC=CC=C5,Active,IC50,4630
127024220,C1CN(CCN1CC2=C(C=C(C=C2)F)F)C3=NC4=C(C=CC(=C4)C#N)N=C3NCCC(F)(F)F.C(=O)(C(F)(F)F)O,Active,IC50,390
127024220,C1CN(CCN1CC2=C(C=C(C=C2)F)F)C3=NC4=C(C=CC(=C4)C#N)N=C3NCCC(F)(F)F.C(=O)(C(F)(F)F)O,Active,IC50,390
127024191,C1CN(CCN1CC2=C(C=C(C=C2)F)F)C3=NC4=C(C=NC=C4)N=C3NCC(F)F.C(=O)(C(F)(F)F)O,Active,IC50,230
127024191,C1CN(CCN1CC2=C(C=C(C=C2)F)F)C3=NC4=C(C=NC=C4)N=C3NCC(F)F.C(=O)(C(F)(F)F)O,Active,IC50,230
90038119,C1CN(CCN1CC2=C(C=CC(=C2)Cl)Cl)C3=NC4=C(C=C(C=C4)C#N)N=C3NC5=CN=CC=C5,Active,IC50,440
90038119,C1CN(CCN1CC2=C(C=CC(=C2)Cl)Cl)C3=NC4=C(C=C(C=C4)C#N)N=C3NC5=CN=CC=C5,Active,IC50,440
127024146,C1CN(CCN1CC2=C(C=CC(=C2)Cl)Cl)C3=NC4=C(C=CC(=C4)C#N)N=C3NC5CC(=O)C5.C(=O)(C(F)(F)F)O,Active,IC50,97
127024146,C1CN(CCN1CC2=C(C=CC(=C2)Cl)Cl)C3=NC4=C(C=CC(=C4)C#N)N=C3NC5CC(=O)C5.C(=O)(C(F)(F)F)O,Active,IC50,97
90039926,C1CN(CCN1CC2=C(C=CC(=C2)Cl)Cl)C3=NC4=CC=CC=C4N=C3NC5=CC=C(C=C5)C#N,Active,IC50,5530
90039926,C1CN(CCN1CC2=C(C=CC(=C2)Cl)Cl)C3=NC4=CC=CC=C4N=C3NC5=CC=C(C=C5)C#N,Active,IC50,5530
127024651,C1CN(CCN1CC2=C(C=CC(=C2)Cl)Cl)C3=NC4=CC=CC=C4N=C3NC5=CC=CC=N5.C(=O)(C(F)(F)F)O,Active,IC50,3290
127024651,C1CN(CCN1CC2=C(C=CC(=C2)Cl)Cl)C3=NC4=CC=CC=C4N=C3NC5=CC=CC=N5.C(=O)(C(F)(F)F)O,Active,IC50,3290
127024763,C1CN(CCN1CC2=C(C=CC(=C2)Cl)Cl)C3=NC4=CC=CC=C4N=C3NC5=NC=CN=C5.C(=O)(C(F)(F)F)O,Active,IC50,2340
127024763,C1CN(CCN1CC2=C(C=CC(=C2)Cl)Cl)C3=NC4=CC=CC=C4N=C3NC5=NC=CN=C5.C(=O)(C(F)(F)F)O,Active,IC50,2340
127024764,C1CN(CCN1CC2=C(C=CC(=C2)Cl)Cl)C3=NC4=CC=CC=C4N=C3NC5=NN=CC=C5.C(=O)(C(F)(F)F)O,Active,IC50,1670
127024764,C1CN(CCN1CC2=C(C=CC(=C2)Cl)Cl)C3=NC4=CC=CC=C4N=C3NC5=NN=CC=C5.C(=O)(C(F)(F)F)O,Active,IC50,1670
127024758,C1CN(CCN1CC2=CC(=C(C=C2F)F)F)C3=NC4=C(C=NC=C4)N=C3NC5=CN=CC=C5.C(=O)(C(F)(F)F)O,Active,IC50,400
127024758,C1CN(CCN1CC2=CC(=C(C=C2F)F)F)C3=NC4=C(C=NC=C4)N=C3NC5=CN=CC=C5.C(=O)(C(F)(F)F)O,Active,IC50,400
127024650,C1CN(CCN1CC2=CC(=CC=C2)Cl)C3=NC4=C(N=CC=C4)N=C3NC5=CC=CC=C5.C(=O)(C(F)(F)F)O,Active,IC50,7670
127024650,C1CN(CCN1CC2=CC(=CC=C2)Cl)C3=NC4=C(N=CC=C4)N=C3NC5=CC=CC=C5.C(=O)(C(F)(F)F)O,Active,IC50,7670
127024649,C1CN(CCN1CC2=CC(=CC=C2)Cl)C3=NC4=CC=CC=C4N=C3NC5=CC=C(C=C5)Br.C(=O)(C(F)(F)F)O,Active,IC50,3030
127024649,C1CN(CCN1CC2=CC(=CC=C2)Cl)C3=NC4=CC=CC=C4N=C3NC5=CC=C(C=C5)Br.C(=O)(C(F)(F)F)O,Active,IC50,3030
127024461,C1CN(CCN1CC2=CC(=CC=C2)Cl)C3=NC4=CC=CC=C4N=C3NC5=CC=C(C=C5)F.C(=O)(C(F)(F)F)O,Active,IC50,5730
127024461,C1CN(CCN1CC2=CC(=CC=C2)Cl)C3=NC4=CC=CC=C4N=C3NC5=CC=C(C=C5)F.C(=O)(C(F)(F)F)O,Active,IC50,5730
127024504,C1CN(CCN1CC2=CC(=CC=C2)Cl)C3=NC4=CC=CC=C4N=C3NC5=CN=CC=C5.C(=O)(C(F)(F)F)O,Active,IC50,1200
127024504,C1CN(CCN1CC2=CC(=CC=C2)Cl)C3=NC4=CC=CC=C4N=C3NC5=CN=CC=C5.C(=O)(C(F)(F)F)O,Active,IC50,1200
9966063,C1CN2C(=N1)SSC2=NC(=O)C3=C(C=C(C=C3)F)F,Active,IC50,190
9966063,C1CN2C(=N1)SSC2=NC(=O)C3=C(C=C(C=C3)F)F,Active,IC50,190
9966063,C1CN2C(=N1)SSC2=NC(=O)C3=C(C=C(C=C3)F)F,Active,IC50,410
9966063,C1CN2C(=N1)SSC2=NC(=O)C3=C(C=C(C=C3)F)F,Active,IC50,410
10224726,C1CN2C(=N1)SSC2=NC(=O)C3=C(N(N=C3)C4=CC=C(C=C4)Cl)C(F)(F)F,Active,IC50,189.7
10224726,C1CN2C(=N1)SSC2=NC(=O)C3=C(N(N=C3)C4=CC=C(C=C4)Cl)C(F)(F)F,Active,IC50,189.7
9856954,C1CN2C(=N1)SSC2=NC(=O)C3=CC(=CC=C3)F,Active,IC50,220
9856954,C1CN2C(=N1)SSC2=NC(=O)C3=CC(=CC=C3)F,Active,IC50,220
9856954,C1CN2C(=N1)SSC2=NC(=O)C3=CC(=CC=C3)F,Active,IC50,240
9856954,C1CN2C(=N1)SSC2=NC(=O)C3=CC(=CC=C3)F,Active,IC50,240
9967340,C1CN2C(=N1)SSC2=NC(=O)C3=CC=C(C=C3)C(F)(F)F,Active,IC50,170
9967340,C1CN2C(=N1)SSC2=NC(=O)C3=CC=C(C=C3)C(F)(F)F,Active,IC50,170
9967340,C1CN2C(=N1)SSC2=NC(=O)C3=CC=C(C=C3)C(F)(F)F,Active,IC50,570
9967340,C1CN2C(=N1)SSC2=NC(=O)C3=CC=C(C=C3)C(F)(F)F,Active,IC50,570
9944074,C1CN2C(=N1)SSC2=NC(=O)C3=CC=C(C=C3)Cl,Active,IC50,270
9944074,C1CN2C(=N1)SSC2=NC(=O)C3=CC=C(C=C3)Cl,Active,IC50,270
9944074,C1CN2C(=N1)SSC2=NC(=O)C3=CC=C(C=C3)Cl,Active,IC50,640
9944074,C1CN2C(=N1)SSC2=NC(=O)C3=CC=C(C=C3)Cl,Active,IC50,640
9965548,C1CN2C(=N1)SSC2=NC(=O)C3=CC=C(C=C3)F,Active,IC50,200
9965548,C1CN2C(=N1)SSC2=NC(=O)C3=CC=C(C=C3)F,Active,IC50,200
9965548,C1CN2C(=N1)SSC2=NC(=O)C3=CC=C(C=C3)F,Active,IC50,370
9965548,C1CN2C(=N1)SSC2=NC(=O)C3=CC=C(C=C3)F,Active,IC50,370
5142438,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CC=C3,Active,IC50,170
5142438,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CC=C3,Active,IC50,170
5142438,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CC=C3,Active,IC50,440
5142438,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CC=C3,Active,IC50,440
9856955,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CC=C3F,Active,IC50,100
9856955,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CC=C3F,Active,IC50,100
9856955,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CC=C3F,Active,IC50,350
9856955,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CC=C3F,Active,IC50,350
10267725,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CC4=CC=CC=C43,Active,IC50,130
10267725,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CC4=CC=CC=C43,Active,IC50,130
10267725,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CC4=CC=CC=C43,Active,IC50,450
10267725,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CC4=CC=CC=C43,Active,IC50,450
9921301,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CO3,Active,IC50,110
9921301,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CO3,Active,IC50,110
9921301,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CO3,Active,IC50,250
9921301,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CO3,Active,IC50,250
9860209,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CS3,Active,IC50,100
9860209,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CS3,Active,IC50,100
9860209,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CS3,Active,IC50,420
9860209,C1CN2C(=N1)SSC2=NC(=O)C3=CC=CS3,Active,IC50,420
9878257,C1CN2C(=N1)SSC2=NC(=O)C3=CC=NO3,Active,IC50,100
9878257,C1CN2C(=N1)SSC2=NC(=O)C3=CC=NO3,Active,IC50,100
9878257,C1CN2C(=N1)SSC2=NC(=O)C3=CC=NO3,Active,IC50,330
9878257,C1CN2C(=N1)SSC2=NC(=O)C3=CC=NO3,Active,IC50,330
10267726,C1CN2C(=N1)SSC2=NC(=O)C3=CC4=CC=CC=C4C=C3,Active,IC50,170
10267726,C1CN2C(=N1)SSC2=NC(=O)C3=CC4=CC=CC=C4C=C3,Active,IC50,170
10267726,C1CN2C(=N1)SSC2=NC(=O)C3=CC4=CC=CC=C4C=C3,Active,IC50,170
10267726,C1CN2C(=N1)SSC2=NC(=O)C3=CC4=CC=CC=C4C=C3,Active,IC50,170
9966813,C1CN2C(=N1)SSC2=NC(=O)C3=CC4=CC=CC=C4S3,Active,IC50,130
9966813,C1CN2C(=N1)SSC2=NC(=O)C3=CC4=CC=CC=C4S3,Active,IC50,130
9966813,C1CN2C(=N1)SSC2=NC(=O)C3=CC4=CC=CC=C4S3,Active,IC50,190
9966813,C1CN2C(=N1)SSC2=NC(=O)C3=CC4=CC=CC=C4S3,Active,IC50,190
9835042,C1CN2C(=N1)SSC2=NC(=O)C3=CN=CC=C3,Active,IC50,133
9835042,C1CN2C(=N1)SSC2=NC(=O)C3=CN=CC=C3,Active,IC50,133
9835042,C1CN2C(=N1)SSC2=NC(=O)C3=CN=CC=C3,Active,IC50,670
9835042,C1CN2C(=N1)SSC2=NC(=O)C3=CN=CC=C3,Active,IC50,670
127024241,C1COCCC1NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,4070
127024241,C1COCCC1NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,4070
90038865,CC(=O)C1=CC=C(C=C1)OC2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,1740
90038865,CC(=O)C1=CC=C(C=C1)OC2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,1740
118159128,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CC(C5)OC(=O)C,Active,IC50,0.6039
9923056,CC(C)(C)C1=CC=C(C=C1)C(=O)N=C2N3CCN=C3SS2,Active,IC50,370
9923056,CC(C)(C)C1=CC=C(C=C1)C(=O)N=C2N3CCN=C3SS2,Active,IC50,370
9923056,CC(C)(C)C1=CC=C(C=C1)C(=O)N=C2N3CCN=C3SS2,Active,IC50,650
9923056,CC(C)(C)C1=CC=C(C=C1)C(=O)N=C2N3CCN=C3SS2,Active,IC50,650
90039136,CC(C)(C)NC1=NC2=C(C=NC(=C2)C#N)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Active,IC50,538
90039136,CC(C)(C)NC1=NC2=C(C=NC(=C2)C#N)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Active,IC50,538
127024821,CC(C)CCNC1=NC2=CC=CC=C2N=C1N3CCN(CC3)CC4=C(C=CC(=C4)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,3980
127024821,CC(C)CCNC1=NC2=CC=CC=C2N=C1N3CCN(CC3)CC4=C(C=CC(=C4)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,3980
127024819,CC(C)CNC1=NC2=CC=CC=C2N=C1N3CCN(CC3)CC4=C(C=CC(=C4)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,6030
127024819,CC(C)CNC1=NC2=CC=CC=C2N=C1N3CCN(CC3)CC4=C(C=CC(=C4)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,6030
127024468,CC(C)NC1=CC(=CC(=C1)C(=O)C2CCN(CC2)C3=NC4=C(C=C(C=C4)C#N)N=C3NC(C)C)Cl,Active,IC50,276
127024468,CC(C)NC1=CC(=CC(=C1)C(=O)C2CCN(CC2)C3=NC4=C(C=C(C=C4)C#N)N=C3NC(C)C)Cl,Active,IC50,276
122420763,CC(C)NC1=NC2=C(C=C(C=C2)C#N)N=C1N3CCC(CC3)[C@@H](C4=C(C=C(C=C4)F)F)F,Active,IC50,82
122420758,CC(C)NC1=NC2=C(C=C(C=C2)C#N)N=C1N3CCC(CC3)[C@@H](C4=C(C=CC(=C4)F)F)F,Active,IC50,82
122420743,CC(C)NC1=NC2=C(C=C(C=C2)C#N)N=C1N3CCC(CC3)[C@H](C4=C(C=C(C=C4)F)F)F,Active,IC50,49
122420743,CC(C)NC1=NC2=C(C=C(C=C2)C#N)N=C1N3CCC(CC3)[C@H](C4=C(C=C(C=C4)F)F)F,Active,IC50,49
127024457,CC(C)NC1=NC2=C(C=C(C=C2)C#N)N=C1N3CCC(CC3)C(C4=C(C=CC(=C4)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,98
127024457,CC(C)NC1=NC2=C(C=C(C=C2)C#N)N=C1N3CCC(CC3)C(C4=C(C=CC(=C4)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,98
155559864,CC(C)NC1=NC2=C(C=C(C=C2)C#N)N=C1N3CCN(CC3)CC4=C(C=CC(=C4)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,310
127024727,CC(C)NC1=NC2=C(C=C(C=C2)C#N)N=C1N3CCN(CC3)CC4=C(C=CC(=C4)F)F.C(=O)(C(F)(F)F)O,Active,IC50,310
127024696,CC(C)NC1=NC2=C(C=CN=C2)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,29
127024696,CC(C)NC1=NC2=C(C=CN=C2)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,29
90037662,CC(C)NC1=NC2=C(C=CN=C2)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Active,IC50,20
90037662,CC(C)NC1=NC2=C(C=CN=C2)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Active,IC50,20
127024452,CC(C)NC1=NC2=C(C=CN=C2)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F.C(=O)(C(F)(F)F)O,Active,IC50,21
127024452,CC(C)NC1=NC2=C(C=CN=C2)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F.C(=O)(C(F)(F)F)O,Active,IC50,21
127024695,CC(C)NC1=NC2=C(C=CN=C2)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F.C(=O)(C(F)(F)F)O,Active,IC50,12
127024695,CC(C)NC1=NC2=C(C=CN=C2)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F.C(=O)(C(F)(F)F)O,Active,IC50,12
127024469,CC(C)NC1=NC2=C(C=NC(=C2)C#N)N=C1N3CCC(CC3)C(=O)C4=CC(=CC(=C4)F)F.C(=O)(C(F)(F)F)O,Active,IC50,28
127024469,CC(C)NC1=NC2=C(C=NC(=C2)C#N)N=C1N3CCC(CC3)C(=O)C4=CC(=CC(=C4)F)F.C(=O)(C(F)(F)F)O,Active,IC50,28
127024116,CC(C)NC1=NC2=C(C=NC(=C2)C#N)N=C1N3CCC(CC3)CC4=C(C=C(C=C4)OC)F.C(=O)(C(F)(F)F)O,Active,IC50,26
127024116,CC(C)NC1=NC2=C(C=NC(=C2)C#N)N=C1N3CCC(CC3)CC4=C(C=C(C=C4)OC)F.C(=O)(C(F)(F)F)O,Active,IC50,26
118180376,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC([C@@H](C3)F)OC4=C(C=C(C=C4)F)F,Active,IC50,0.0378
118159240,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)C(=O)C4=C(C=CC(=C4)Cl)F,Active,IC50,0.0138
118180374,CC(C)NC1=NC2=C(CCN(C2)CN3CCOCC3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Active,IC50,0.0626
118159151,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)C(=O)C4=C(C=CC(=C4)Cl)F,Active,IC50,9800
118159151,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)C(=O)C4=C(C=CC(=C4)Cl)F,Active,IC50,9800
118159151,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)C(=O)C4=C(C=CC(=C4)Cl)F,Active,IC50,9800
118159272,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F,Active,IC50,8500
118159272,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F,Active,IC50,8500
118159272,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F,Active,IC50,8500
118159235,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Active,IC50,9500
118159235,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Active,IC50,9500
118159235,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Active,IC50,9500
118159276,CC(C)NC1=NC2=C(CN(CC2)C)N=C1N3CCC(CC3)C(=O)C4=C(C=CC(=C4)Cl)F,Active,IC50,8800
118159276,CC(C)NC1=NC2=C(CN(CC2)C)N=C1N3CCC(CC3)C(=O)C4=C(C=CC(=C4)Cl)F,Active,IC50,8800
118159276,CC(C)NC1=NC2=C(CN(CC2)C)N=C1N3CCC(CC3)C(=O)C4=C(C=CC(=C4)Cl)F,Active,IC50,8800
127024252,CC(C)NC1=NC2=CC(=NC=C2N=C1N3CCC(CC3)C(=O)C4=CC(=CC(=C4)F)F)C(=O)N(C)C.C(=O)(C(F)(F)F)O,Active,IC50,16
127024252,CC(C)NC1=NC2=CC(=NC=C2N=C1N3CCC(CC3)C(=O)C4=CC(=CC(=C4)F)F)C(=O)N(C)C.C(=O)(C(F)(F)F)O,Active,IC50,16
127024697,CC(C)NC1=NC2=CC(=NC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)Cl)F)C(=O)N(C)C.C(=O)(C(F)(F)F)O,Active,IC50,6
127024697,CC(C)NC1=NC2=CC(=NC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)Cl)F)C(=O)N(C)C.C(=O)(C(F)(F)F)O,Active,IC50,6
127024563,CC(C)NC1=NC2=CC(=NC=C2N=C1N3CCN(CC3)CC4=C(C=C(C=C4)F)F)C(=O)N(C)C.C(=O)(C(F)(F)F)O,Active,IC50,40
127024563,CC(C)NC1=NC2=CC(=NC=C2N=C1N3CCN(CC3)CC4=C(C=C(C=C4)F)F)C(=O)N(C)C.C(=O)(C(F)(F)F)O,Active,IC50,40
155532393,CC(C)NC1=NC2=CC=CC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)Cl)F.Cl,Active,IC50,51
127024820,CC(C)NC1=NC2=CC=CC=C2N=C1N3CCN(CC3)CC4=C(C=CC(=C4)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,3310
127024820,CC(C)NC1=NC2=CC=CC=C2N=C1N3CCN(CC3)CC4=C(C=CC(=C4)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,3310
127024156,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)[C@H](C4=C(C=C(C=C4)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,14
127024156,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)[C@H](C4=C(C=C(C=C4)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,14
127024343,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)C(=O)C4=C(C=C(C=C4)OC)F.C(=O)(C(F)(F)F)O,Active,IC50,54
127024343,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)C(=O)C4=C(C=C(C=C4)OC)F.C(=O)(C(F)(F)F)O,Active,IC50,54
127024502,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,6
127024502,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,6
127024565,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)CC4=C(C=C(C=C4)OC)F.C(=O)(C(F)(F)F)O,Active,IC50,15
127024565,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)CC4=C(C=C(C=C4)OC)F.C(=O)(C(F)(F)F)O,Active,IC50,15
127024253,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)C#N)F.C(=O)(C(F)(F)F)O,Active,IC50,72
127024253,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)C#N)F.C(=O)(C(F)(F)F)O,Active,IC50,72
127024301,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)Cl)F.C(=O)(C(F)(F)F)O,Active,IC50,7
127024301,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)Cl)F.C(=O)(C(F)(F)F)O,Active,IC50,7
127024115,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F.C(=O)(C(F)(F)F)O,Active,IC50,4
127024115,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F.C(=O)(C(F)(F)F)O,Active,IC50,4
127024114,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F.C(=O)(C(F)(F)F)O,Active,IC50,6
127024114,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F.C(=O)(C(F)(F)F)O,Active,IC50,6
127024201,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OCF)F.C(=O)(C(F)(F)F)O,Active,IC50,8
127024201,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OCF)F.C(=O)(C(F)(F)F)O,Active,IC50,8
90038724,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)OC4=CC=CC(=C4)OC.C(=O)(C(F)(F)F)O,Active,IC50,1000
90038724,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)OC4=CC=CC(=C4)OC.C(=O)(C(F)(F)F)O,Active,IC50,1000
127024302,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCN(CC3)CC4=CC(=CC=C4)OC.C(=O)(C(F)(F)F)O,Active,IC50,44
127024302,CC(C)NC1=NC2=CN=NC=C2N=C1N3CCN(CC3)CC4=CC(=CC=C4)OC.C(=O)(C(F)(F)F)O,Active,IC50,44
127024196,CC(C)OCCNC1=NC2=CC=CC=C2N=C1N3CCN(CC3)CC4=C(C=CC(=C4)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,3330
127024196,CC(C)OCCNC1=NC2=CC=CC=C2N=C1N3CCN(CC3)CC4=C(C=CC(=C4)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,3330
127024551,CC(C1=CC=C(C=C1)OC2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5)O.C(=O)(C(F)(F)F)O,Active,IC50,6040
127024551,CC(C1=CC=C(C=C1)OC2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5)O.C(=O)(C(F)(F)F)O,Active,IC50,6040
127024564,CC[C@@H](C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F.C(=O)(C(F)(F)F)O,Active,IC50,30
127024564,CC[C@@H](C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F.C(=O)(C(F)(F)F)O,Active,IC50,30
127024503,CC[C@H](C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F.C(=O)(C(F)(F)F)O,Active,IC50,21
127024503,CC[C@H](C)NC1=NC2=CN=NC=C2N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F.C(=O)(C(F)(F)F)O,Active,IC50,21
127024766,CC1=C(C(=CC=C1)CN2CCN(CC2)C3=NC4=CC=CC=C4N=C3NC5CC5)C.C(=O)(C(F)(F)F)O,Active,IC50,3640
127024766,CC1=C(C(=CC=C1)CN2CCN(CC2)C3=NC4=CC=CC=C4N=C3NC5CC5)C.C(=O)(C(F)(F)F)O,Active,IC50,3640
9921833,CC1=C(C(=NO1)C)C(=O)N=C2N3CCN=C3SS2,Active,IC50,350
9921833,CC1=C(C(=NO1)C)C(=O)N=C2N3CCN=C3SS2,Active,IC50,350
9921833,CC1=C(C(=NO1)C)C(=O)N=C2N3CCN=C3SS2,Active,IC50,460
9921833,CC1=C(C(=NO1)C)C(=O)N=C2N3CCN=C3SS2,Active,IC50,460
9967985,CC1=C(C(=NO1)C2=CC=CC=C2)C(=O)N=C3N4CCN=C4SS3,Active,IC50,2460
9967985,CC1=C(C(=NO1)C2=CC=CC=C2)C(=O)N=C3N4CCN=C4SS3,Active,IC50,2460
127024546,CC1=C(C=C(C=C1Cl)F)S(=O)(=O)N2CCN(CC2)C3=NC4=C(C=CC(=C4)C#N)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,960
127024546,CC1=C(C=C(C=C1Cl)F)S(=O)(=O)N2CCN(CC2)C3=NC4=C(C=CC(=C4)C#N)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,960
127024194,CC1=C(C=CC(=C1)C(=O)N2CCN(CC2)C3=NC4=CC=CC=C4N=C3NC5CC5)Cl.C(=O)(C(F)(F)F)O,Active,IC50,720
127024194,CC1=C(C=CC(=C1)C(=O)N2CCN(CC2)C3=NC4=CC=CC=C4N=C3NC5CC5)Cl.C(=O)(C(F)(F)F)O,Active,IC50,720
90038968,CC1=C2C(=C(N=N1)C)N=C(C(=N2)NC(C)C)N3CCC(CC3)OC4=C(C=C(C=C4)F)F.C(=O)(C(F)(F)F)O,Active,IC50,60
155512341,CC1=C2C(=CN=N1)N=C(C(=N2)NC(C)C)N3CCC(CC3)OC4=C(C=C(C=C4)F)F.C(=O)(C(F)(F)F)O,Active,IC50,31
127024283,CC1=CC(=C(C=C1)C)CN2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,380
127024283,CC1=CC(=C(C=C1)C)CN2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,380
127024545,CC1=CC(=C(C=C1Cl)C)S(=O)(=O)N2CCN(CC2)C3=NC4=C(C=CC(=C4)C#N)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,450
127024545,CC1=CC(=C(C=C1Cl)C)S(=O)(=O)N2CCN(CC2)C3=NC4=C(C=CC(=C4)C#N)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,450
118308635,CC1=CC(=C2C(=C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=CC(=C4)Cl)Cl)NC5CC5)C,Active,IC50,5310
118308635,CC1=CC(=C2C(=C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=CC(=C4)Cl)Cl)NC5CC5)C,Active,IC50,5310
9943518,CC1=CC(=CC=C1)C(=O)N=C2N3CCN=C3SS2,Active,IC50,140
9943518,CC1=CC(=CC=C1)C(=O)N=C2N3CCN=C3SS2,Active,IC50,140
9943518,CC1=CC(=CC=C1)C(=O)N=C2N3CCN=C3SS2,Active,IC50,790
9943518,CC1=CC(=CC=C1)C(=O)N=C2N3CCN=C3SS2,Active,IC50,790
9835387,CC1=CC(=CC=C1)C(=O)NC(=S)N2CCNC2=S,Active,IC50,3800
9835387,CC1=CC(=CC=C1)C(=O)NC(=S)N2CCNC2=S,Active,IC50,3800
90039111,CC1=CC(=CC=C1)CN2CCN(CC2)C3=NC4=C(C=CC=N4)N=C3NC5CC5,Active,IC50,840
90039111,CC1=CC(=CC=C1)CN2CCN(CC2)C3=NC4=C(C=CC=N4)N=C3NC5CC5,Active,IC50,840
90038768,CC1=CC(=NO1)C(=O)N2CCN(CC2)C3=NC4=CC=CC=C4N=C3NC5CC5,Active,IC50,3210
90038768,CC1=CC(=NO1)C(=O)N2CCN(CC2)C3=NC4=CC=CC=C4N=C3NC5CC5,Active,IC50,3210
90038235,CC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C3=NC4=C(C=CC(=C4)C#N)N=C3NC5CC5,Active,IC50,4740
90038235,CC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C3=NC4=C(C=CC(=C4)C#N)N=C3NC5CC5,Active,IC50,4740
127024732,CC1=CC=CC=C1C(=O)C2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,5780
127024732,CC1=CC=CC=C1C(=O)C2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,5780
90039689,CC1=CC2=C(C=N1)N=C(C(=N2)NC3CC3)N4CCC(CC4)[C@@H](C5=C(C=CC(=C5)F)F)F,Active,IC50,11
90039689,CC1=CC2=C(C=N1)N=C(C(=N2)NC3CC3)N4CCC(CC4)[C@@H](C5=C(C=CC(=C5)F)F)F,Active,IC50,11
127024295,CC1=CC2=C(C=N1)N=C(C(=N2)NC3CC3)N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,6
127024295,CC1=CC2=C(C=N1)N=C(C(=N2)NC3CC3)N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,6
90038652,CC1=CC2=C(C=N1)N=C(C(=N2)NC3CC3)N4CCC(CC4)C(C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,7
90038652,CC1=CC2=C(C=N1)N=C(C(=N2)NC3CC3)N4CCC(CC4)C(C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,7
127024735,CC1=CC2=C(C=N1)N=C(C(=N2)NC3CC3)N4CCC(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,20
127024735,CC1=CC2=C(C=N1)N=C(C(=N2)NC3CC3)N4CCC(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,20
90038198,CC1=CC2=C(C=N1)N=C(C(=N2)NC3CC3)N4CCC(CC4)CN5C=C(C=CC5=O)Cl,Active,IC50,770
155524412,CC1=CC2=C(C=N1)N=C(C(=N2)NC3CC3)N4CCC(CC4)CN5C=C(C=CC5=O)Cl.C(=O)(C(F)(F)F)O,Active,IC50,770
90038064,CC1=CC2=C(C=N1)N=C(C(=N2)NC3CC3)N4CCC(CC4)S(=O)(=O)C5=CC=C(C=C5)F.C(=O)(C(F)(F)F)O,Active,IC50,93
90038064,CC1=CC2=C(C=N1)N=C(C(=N2)NC3CC3)N4CCC(CC4)S(=O)(=O)C5=CC=C(C=C5)F.C(=O)(C(F)(F)F)O,Active,IC50,93
127024466,CC1=NC=CC2=C1N=C(C(=N2)NC3CC3)N4CCC(CC4)C(C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,9
127024466,CC1=NC=CC2=C1N=C(C(=N2)NC3CC3)N4CCC(CC4)C(C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,9
118308547,CC1=NC=CC2=C1N=C(C(=N2)NC3CC3)N4CCC(CC4)C(C5=C(C=CC(=C5)F)F)(F)F,Active,IC50,45
118308547,CC1=NC=CC2=C1N=C(C(=N2)NC3CC3)N4CCC(CC4)C(C5=C(C=CC(=C5)F)F)(F)F,Active,IC50,45
127024467,CC1=NC=CC2=C1N=C(C(=N2)NC3CC3)N4CCC(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,2
127024467,CC1=NC=CC2=C1N=C(C(=N2)NC3CC3)N4CCC(CC4)CC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,2
90038529,CC1=NC=CC2=C1N=C(C(=N2)NC3CC3)N4CCC(CC4)CN5C=CC(=CC5=O)F,Active,IC50,380
155569123,CC1=NC=CC2=C1N=C(C(=N2)NC3CC3)N4CCC(CC4)CN5C=CC(=CC5=O)F.C(=O)(C(F)(F)F)O,Active,IC50,380
127024294,CC1=NC=CC2=C1N=C(C(=N2)NC3CC3)N4CCC(CC4)OC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,18
127024294,CC1=NC=CC2=C1N=C(C(=N2)NC3CC3)N4CCC(CC4)OC5=C(C=C(C=C5)F)F.C(=O)(C(F)(F)F)O,Active,IC50,18
118159181,CC1C2=C(CCN1C(=O)COC)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC(C)C,Active,IC50,0.091
155529253,CC1CC1NC2=NC3=CN=NC=C3N=C2N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F.C(=O)(C(F)(F)F)O,Active,IC50,145
118180377,CC1CN(CC2=C1N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC(C)C)C(=O)N(C)C,Active,IC50,0.0138
127024402,CCNC1=NC2=C(C=CN=C2)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F.C(=O)(C(F)(F)F)O,Active,IC50,39
127024402,CCNC1=NC2=C(C=CN=C2)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F.C(=O)(C(F)(F)F)O,Active,IC50,39
127024553,CCOC1=CC=C(C=C1)OC2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,1023
127024553,CCOC1=CC=C(C=C1)OC2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,1023
127024117,CN(C)C(=O)C1=NC=C2C(=C1)N=C(C(=N2)N3CCC(CC3)[C@@H](C4=C(C=C(C=C4)F)F)F)NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,10
127024117,CN(C)C(=O)C1=NC=C2C(=C1)N=C(C(=N2)N3CCC(CC3)[C@@H](C4=C(C=C(C=C4)F)F)F)NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,10
127024733,CN(C)C(=O)C1=NC=C2C(=C1)N=C(C(=N2)N3CCC(CC3)[C@H](C4=C(C=C(C=C4)F)F)F)NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,8
127024733,CN(C)C(=O)C1=NC=C2C(=C1)N=C(C(=N2)N3CCC(CC3)[C@H](C4=C(C=C(C=C4)F)F)F)NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,8
90038977,CN(C)C(=O)C1=NC=C2C(=C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CC5,Active,IC50,5
90038977,CN(C)C(=O)C1=NC=C2C(=C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CC5,Active,IC50,5
127024566,CN(C)C(=O)C1=NC=C2C(=C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F.C(=O)(C(F)(F)F)O,Active,IC50,65
127024566,CN(C)C(=O)C1=NC=C2C(=C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F.C(=O)(C(F)(F)F)O,Active,IC50,65
90038513,CN(C)C(=O)C1=NC=C2C(=C1)N=C(C(=N2)N3CCN(CC3)C(=O)C4=C(C=CC(=C4)F)Cl)NC5CC5,Active,IC50,1572
90038513,CN(C)C(=O)C1=NC=C2C(=C1)N=C(C(=N2)N3CCN(CC3)C(=O)C4=C(C=CC(=C4)F)Cl)NC5CC5,Active,IC50,1572
127024292,CN(C)C(=O)C1=NC=C2C(=C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)OC)F)NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,939
127024292,CN(C)C(=O)C1=NC=C2C(=C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)OC)F)NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,939
90038218,CN(C)C(=O)C1=NC=CC2=C1N=C(C(=N2)NC3CC3)N4CCC(CC4)OC5=C(C=C(C=C5)OC)F,Active,IC50,54
90038218,CN(C)C(=O)C1=NC=CC2=C1N=C(C(=N2)NC3CC3)N4CCC(CC4)OC5=C(C=C(C=C5)OC)F,Active,IC50,54
118159362,CN(C)C(=O)N1CCC2=C(C1)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Active,IC50,9100
118159362,CN(C)C(=O)N1CCC2=C(C1)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Active,IC50,9100
118159362,CN(C)C(=O)N1CCC2=C(C1)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Active,IC50,9100
118159174,CN1CCC2=C(C1)N=C(C(=N2)NC3CC3)N4CCC(CC4)C(C5=C(C=C(C=C5)F)F)F,Active,IC50,9400
118159174,CN1CCC2=C(C1)N=C(C(=N2)NC3CC3)N4CCC(CC4)C(C5=C(C=C(C=C5)F)F)F,Active,IC50,9400
118159174,CN1CCC2=C(C1)N=C(C(=N2)NC3CC3)N4CCC(CC4)C(C5=C(C=C(C=C5)F)F)F,Active,IC50,9400
155563953,CN1CCN(CC1)C(=O)C2=NC=C3C(=C2)N=C(C(=N3)N4CCC(CC4)C(=O)C5=C(C=CC(=C5)C#N)F)NC6CC6.C(=O)(C(F)(F)F)O,Active,IC50,54
127024392,COC1=CC(=C(C=C1)Br)C(=O)N2CCN(CC2)C3=NC4=CC=CC=C4N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,7550
127024392,COC1=CC(=C(C=C1)Br)C(=O)N2CCN(CC2)C3=NC4=CC=CC=C4N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,7550
155553228,COC1=CC(=C(C=C1)C(=O)C2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5)F.C(=O)(C(F)(F)F)O,Active,IC50,21
155525846,COC1=CC(=C(C=C1)C(=O)C2CCN(CC2)C3=NC4=C(C=CN=C4C#N)N=C3NC5CC5)F.C(=O)(C(F)(F)F)O,Active,IC50,43
155514894,COC1=CC(=C(C=C1)C(=O)C2CCN(CC2)C3=NC4=C(C=CN=C4N5CCOCC5)N=C3NC6CC6)F.C(=O)(C(F)(F)F)O,Active,IC50,717
127024400,COC1=CC(=C(C=C1)CN2CCN(CC2)C3=NC4=C(C=CN=C4C#N)N=C3NC5CC5)F.C(=O)(C(F)(F)F)O,Active,IC50,88
127024400,COC1=CC(=C(C=C1)CN2CCN(CC2)C3=NC4=C(C=CN=C4C#N)N=C3NC5CC5)F.C(=O)(C(F)(F)F)O,Active,IC50,88
127024640,COC1=CC(=C(C=C1)CN2CCN(CC2)C3=NC4=CN=C(C=C4N=C3NC5CC5)N6CCOCC6)F,Active,IC50,92
155523116,COC1=CC(=C(C=C1)CN2CCN(CC2)C3=NC4=CN=C(C=C4N=C3NC5CC5)N6CCOCC6)F.C(=O)(C(F)(F)F)O,Active,IC50,92
155525944,COC1=CC(=C(C=C1)OC2CCN(CC2)C3=NC4=C(C=CN=C4N5CCOCC5)N=C3NC6CC6)F.C(=O)(C(F)(F)F)O,Active,IC50,114
127024604,COC1=CC(=C(C=C1)OC2CCN(CC2)C3=NC4=C(C=NC=C4)N=C3NC5CC5)F.C(=O)(C(F)(F)F)O,Active,IC50,44
127024604,COC1=CC(=C(C=C1)OC2CCN(CC2)C3=NC4=C(C=NC=C4)N=C3NC5CC5)F.C(=O)(C(F)(F)F)O,Active,IC50,44
118308624,COC1=CC(=C(C=C1)OC2CCN(CC2)C3=NC4=CN=NC=C4N=C3NC5CC5)F,Active,IC50,36
127024291,COC1=CC(=C(C=C1)OC2CCN(CC2)C3=NC4=CN=NC=C4N=C3NC5CC5)F.C(=O)(C(F)(F)F)O,Active,IC50,20
127024291,COC1=CC(=C(C=C1)OC2CCN(CC2)C3=NC4=CN=NC=C4N=C3NC5CC5)F.C(=O)(C(F)(F)F)O,Active,IC50,20
9835741,COC1=CC=C(C=C1)C(=O)N=C2N3CCN=C3SS2,Active,IC50,210
9835741,COC1=CC=C(C=C1)C(=O)N=C2N3CCN=C3SS2,Active,IC50,210
9835741,COC1=CC=C(C=C1)C(=O)N=C2N3CCN=C3SS2,Active,IC50,830
9835741,COC1=CC=C(C=C1)C(=O)N=C2N3CCN=C3SS2,Active,IC50,830
127024390,COC1=CC=C(C=C1)NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)CC5=CC(=CC=C5)Cl.C(=O)(C(F)(F)F)O,Active,IC50,6140
127024390,COC1=CC=C(C=C1)NC2=NC3=CC=CC=C3N=C2N4CCN(CC4)CC5=CC(=CC=C5)Cl.C(=O)(C(F)(F)F)O,Active,IC50,6140
118308644,COC1=CC=C(C=C1)OC2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5,Active,IC50,190
118308644,COC1=CC=C(C=C1)OC2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5,Active,IC50,190
9965902,COC1=CC=CC(=C1)C(=O)N=C2N3CCN=C3SS2,Active,IC50,310
9965902,COC1=CC=CC(=C1)C(=O)N=C2N3CCN=C3SS2,Active,IC50,310
9965902,COC1=CC=CC(=C1)C(=O)N=C2N3CCN=C3SS2,Active,IC50,400
9965902,COC1=CC=CC(=C1)C(=O)N=C2N3CCN=C3SS2,Active,IC50,400
127024160,COC1=CC=CC=C1C(=O)C2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,1920
127024160,COC1=CC=CC=C1C(=O)C2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,1920
127024448,COC1=CC2=C(C=C1)N=C(C(=N2)NC3CC3)N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,3360
127024448,COC1=CC2=C(C=C1)N=C(C(=N2)NC3CC3)N4CCN(CC4)CC5=C(C=CC(=C5)Cl)Cl.C(=O)(C(F)(F)F)O,Active,IC50,3360
127024456,COC1=NC=C2C(=C1)N=C(C(=N2)N3CCC(CC3)CC4=C(C=C(C=C4)F)F)NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,29
127024456,COC1=NC=C2C(=C1)N=C(C(=N2)N3CCC(CC3)CC4=C(C=C(C=C4)F)F)NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,29
90039415,COCCCNC1=NC2=CC=CC=C2N=C1N3CCN(CC3)CC4=C(C=CC(=C4)Cl)Cl,Active,IC50,1940
90039415,COCCCNC1=NC2=CC=CC=C2N=C1N3CCN(CC3)CC4=C(C=CC(=C4)Cl)Cl,Active,IC50,1940
90037804,COCCNC1=NC2=C(C=C(C=C2)C#N)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F,Active,IC50,340
90037804,COCCNC1=NC2=C(C=C(C=C2)C#N)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F,Active,IC50,340
90038615,COCCNC1=NC2=C(C=C(C=C2)C#N)N=C1N3CCC(CC3)CC4=C(C=C(C=C4)F)F,Active,IC50,250
90038615,COCCNC1=NC2=C(C=C(C=C2)C#N)N=C1N3CCC(CC3)CC4=C(C=C(C=C4)F)F,Active,IC50,250
127024289,COCCNC1=NC2=C(C=NC=C2)N=C1N3CCC(CC3)CC4=C(C=C(C=C4)F)F.C(=O)(C(F)(F)F)O,Active,IC50,30
127024289,COCCNC1=NC2=C(C=NC=C2)N=C1N3CCC(CC3)CC4=C(C=C(C=C4)F)F.C(=O)(C(F)(F)F)O,Active,IC50,30
90038095,COCCNC1=NC2=C(C=NC=C2)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F.C(=O)(C(F)(F)F)O,Active,IC50,670
90038095,COCCNC1=NC2=C(C=NC=C2)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F.C(=O)(C(F)(F)F)O,Active,IC50,670
90038163,CS(=O)(=O)C1=CC(=C(C=C1)C(=O)N2CCN(CC2)C3=NC4=CC=CC=C4N=C3NC5CC5)Cl,Active,IC50,1030
90038163,CS(=O)(=O)C1=CC(=C(C=C1)C(=O)N2CCN(CC2)C3=NC4=CC=CC=C4N=C3NC5CC5)Cl,Active,IC50,1030
127024202,CS(=O)(=O)C1=CC=C(C=C1)C(=O)N2CCN(CC2)C3=NC4=CC=CC=C4N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,530
127024202,CS(=O)(=O)C1=CC=C(C=C1)C(=O)N2CCN(CC2)C3=NC4=CC=CC=C4N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,530
127024447,CSC1=CC(=C(C=C1)F)C(=O)C2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,478
127024447,CSC1=CC(=C(C=C1)F)C(=O)C2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,478
127024401,CSC1=CC(=C(C=C1)OC2CCN(CC2)C3=NC4=CN=NC=C4N=C3NC5CC5)F.C(=O)(C(F)(F)F)O,Active,IC50,14
127024401,CSC1=CC(=C(C=C1)OC2CCN(CC2)C3=NC4=CN=NC=C4N=C3NC5CC5)F.C(=O)(C(F)(F)F)O,Active,IC50,14
127024779,CSC1=CC=C(C=C1)OC2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,146
127024779,CSC1=CC=C(C=C1)OC2CCN(CC2)C3=NC4=C(C=CN=C4)N=C3NC5CC5.C(=O)(C(F)(F)F)O,Active,IC50,146
118159237,C[C@@H](C(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F)OC,Inactive,IC50,111000
118159237,C[C@@H](C(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F)OC,Inactive,IC50,111000
118180379,C[C@@H](CCO)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,107100
118180379,C[C@@H](CCO)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,107100
118159340,C[C@H](C(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F)OC,Inactive,IC50,64000
118159340,C[C@H](C(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F)OC,Inactive,IC50,64000
118159287,C1CN(CCC1OC2=C(C=C(C=C2)F)F)C3=NC4=C(CCN(C4)C(=O)C(F)F)N=C3NCC(F)F,Inactive,IC50,110600
118159287,C1CN(CCC1OC2=C(C=C(C=C2)F)F)C3=NC4=C(CCN(C4)C(=O)C(F)F)N=C3NCC(F)F,Inactive,IC50,110600
118159293,C1CN(CCC1OC2=C(C=C(C=C2)F)F)C3=NC4=C(CN(CC4)C(=O)C(F)F)N=C3NCC(F)F,Inactive,IC50,78800
118159293,C1CN(CCC1OC2=C(C=C(C=C2)F)F)C3=NC4=C(CN(CC4)C(=O)C(F)F)N=C3NCC(F)F,Inactive,IC50,78800
118159164,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)N[C@H]5CCOC5,Inactive,IC50,58700
118159164,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)N[C@H]5CCOC5,Inactive,IC50,58700
118159309,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CC(C5)(F)F,Inactive,IC50,35900
118159309,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CC(C5)(F)F,Inactive,IC50,35900
118159301,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CC(C5)O,Inactive,IC50,61500
118159301,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CC(C5)O,Inactive,IC50,61500
118159301,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CC(C5)O,Inactive,IC50,78000
118159301,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CC(C5)O,Inactive,IC50,78000
118159128,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CC(C5)OC(=O)C,Inactive,IC50,113500
118159128,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CC(C5)OC(=O)C,Inactive,IC50,113500
118159128,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CC(C5)OC(=O)C,Inactive,IC50,603900
118159128,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CC(C5)OC(=O)C,Inactive,IC50,603900
118159161,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CCC5,Inactive,IC50,55000
118159161,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CCC5,Inactive,IC50,55000
118159289,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F,Inactive,IC50,49700
118159289,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F,Inactive,IC50,49700
118159377,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)OC)F)NC5CCC5,Inactive,IC50,19900
118159377,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)OC)F)NC5CCC5,Inactive,IC50,19900
118159217,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)N[C@@H]5CCOC5,Inactive,IC50,63200
118159217,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)N[C@@H]5CCOC5,Inactive,IC50,63200
118159198,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)N[C@H]5CCOC5,Inactive,IC50,97800
118159198,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)N[C@H]5CCOC5,Inactive,IC50,97800
118159145,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)NC5CC(C5)F,Inactive,IC50,185900
118159145,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)NC5CC(C5)F,Inactive,IC50,185900
118159238,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)NC5CC(C5)O,Inactive,IC50,122000
118159238,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)NC5CC(C5)O,Inactive,IC50,122000
118159193,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)NC5CC(C5)OC(=O)C,Inactive,IC50,219800
118159193,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)NC5CC(C5)OC(=O)C,Inactive,IC50,219800
118159165,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)NC5CCC5,Inactive,IC50,43700
118159165,CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)NC5CCC5,Inactive,IC50,43700
118159402,CC(=O)N1CCC2=C(C1)N=C(C(=N2)NC3CCC3)N4CCC(CC4)OC5=C(C=C(C=C5)OC)F,Inactive,IC50,12000
118159402,CC(=O)N1CCC2=C(C1)N=C(C(=N2)NC3CCC3)N4CCC(CC4)OC5=C(C=C(C=C5)OC)F,Inactive,IC50,12000
118159394,CC(=O)N1CCC2=C(C1)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,11500
118159394,CC(=O)N1CCC2=C(C1)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,11500
118159229,CC(C)C(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)NC(C)C,Inactive,IC50,29000
118159229,CC(C)C(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)NC(C)C,Inactive,IC50,29000
118159140,CC(C)NC1=NC2=C(CCN(C2)C(=O)[C@@H]3CCCN3C)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,78100
118159140,CC(C)NC1=NC2=C(CCN(C2)C(=O)[C@@H]3CCCN3C)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,78100
118159339,CC(C)NC1=NC2=C(CCN(C2)C(=O)C(C)OC)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,16800
118159339,CC(C)NC1=NC2=C(CCN(C2)C(=O)C(C)OC)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,16800
118159269,CC(C)NC1=NC2=C(CCN(C2)C(=O)C(F)F)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,129200
118159269,CC(C)NC1=NC2=C(CCN(C2)C(=O)C(F)F)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,129200
118159327,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)[C@@H](C4=C(C=C(C=C4)F)F)F,Inactive,IC50,27400
118159327,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)[C@@H](C4=C(C=C(C=C4)F)F)F,Inactive,IC50,27400
118159318,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)[C@H](C4=C(C=C(C=C4)F)F)F,Inactive,IC50,37800
118159318,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)[C@H](C4=C(C=C(C=C4)F)F)F,Inactive,IC50,37800
118159216,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F,Inactive,IC50,13400
118159216,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F,Inactive,IC50,13400
118159242,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)C#N)F,Inactive,IC50,86600
118159242,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)C#N)F,Inactive,IC50,86600
91810771,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,13800
91810771,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,24600
91810771,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,24600
91810771,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,33700
91810771,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,33700
118159385,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F,Inactive,IC50,74100
118159385,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F,Inactive,IC50,74100
131972585,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=CC(=C4)Cl)F,Inactive,IC50,13800
118159118,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCN(CC3)CC4=C(C=C(C=C4)C#N)F,Inactive,IC50,362900
118159118,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCN(CC3)CC4=C(C=C(C=C4)C#N)F,Inactive,IC50,362900
118159375,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCN(CC3)CC4=C(C=C(C=C4)F)F,Inactive,IC50,27000
118159375,CC(C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCN(CC3)CC4=C(C=C(C=C4)F)F,Inactive,IC50,27000
118159320,CC(C)NC1=NC2=C(CCN(C2)C(=O)C3=CC=NO3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,38700
118159320,CC(C)NC1=NC2=C(CCN(C2)C(=O)C3=CC=NO3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,38700
118159281,CC(C)NC1=NC2=C(CCN(C2)C(=O)C3CC3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,340200
118159281,CC(C)NC1=NC2=C(CCN(C2)C(=O)C3CC3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,340200
118159231,CC(C)NC1=NC2=C(CCN(C2)C(=O)C3CCCO3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,17900
118159231,CC(C)NC1=NC2=C(CCN(C2)C(=O)C3CCCO3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,17900
118159267,CC(C)NC1=NC2=C(CCN(C2)C(=O)CC#N)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,55200
118159267,CC(C)NC1=NC2=C(CCN(C2)C(=O)CC#N)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,55200
118159376,CC(C)NC1=NC2=C(CCN(C2)C(=O)COC)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,71500
118159376,CC(C)NC1=NC2=C(CCN(C2)C(=O)COC)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,71500
118159213,CC(C)NC1=NC2=C(CCN(C2)C(=O)N(C)C)N=C1N3CCC(CC3)C(=O)C4=C(C=CC(=C4)Cl)F,Inactive,IC50,32700
118159153,CC(C)NC1=NC2=C(CCN(C2)C(=O)N(C)C)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F,Inactive,IC50,19700
118159153,CC(C)NC1=NC2=C(CCN(C2)C(=O)N(C)C)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F,Inactive,IC50,19700
118159250,CC(C)NC1=NC2=C(CCN(C2)C(=O)N(C)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,10400
118159250,CC(C)NC1=NC2=C(CCN(C2)C(=O)N(C)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,10400
118159393,CC(C)NC1=NC2=C(CCN(C2)C(=O)N(C)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F,Inactive,IC50,35000
118159393,CC(C)NC1=NC2=C(CCN(C2)C(=O)N(C)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F,Inactive,IC50,35000
118857197,CC(C)NC1=NC2=C(CCN(C2)C(=O)N(C)C)N=C1N3CCC(CC3)OC4=C(C=CC(=C4)Cl)F,Inactive,IC50,32700
118159228,CC(C)NC1=NC2=C(CCN(C2)C(=O)N3CCCC3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,391000
118159228,CC(C)NC1=NC2=C(CCN(C2)C(=O)N3CCCC3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,391000
118159248,CC(C)NC1=NC2=C(CCN(C2)C(=O)N3CCOCC3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,62600
118159248,CC(C)NC1=NC2=C(CCN(C2)C(=O)N3CCOCC3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,62600
118159334,CC(C)NC1=NC2=C(CCN(C2)C(=O)NCCOC)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,29800
118159334,CC(C)NC1=NC2=C(CCN(C2)C(=O)NCCOC)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,29800
118159177,CC(C)NC1=NC2=C(CCN(C2)C(=O)OC)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,129500
118159177,CC(C)NC1=NC2=C(CCN(C2)C(=O)OC)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,129500
118159326,CC(C)NC1=NC2=C(CCN(C2)C)N=C1N3CCC(CC3)C(=O)C4=C(C=CC(=C4)Cl)F,Inactive,IC50,13700
118159344,CC(C)NC1=NC2=C(CCN(C2)C)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F,Inactive,IC50,30300
118159344,CC(C)NC1=NC2=C(CCN(C2)C)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F,Inactive,IC50,30300
118159398,CC(C)NC1=NC2=C(CCN(C2)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,90100
118159398,CC(C)NC1=NC2=C(CCN(C2)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,90100
118159150,CC(C)NC1=NC2=C(CCN(C2)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F,Inactive,IC50,140200
118159150,CC(C)NC1=NC2=C(CCN(C2)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F,Inactive,IC50,140200
118857198,CC(C)NC1=NC2=C(CCN(C2)C)N=C1N3CCC(CC3)OC4=C(C=CC(=C4)Cl)F,Inactive,IC50,13700
118159387,CC(C)NC1=NC2=C(CCN(C2)C=O)N=C1N3CCC(CC3)[C@@H](C4=C(C=C(C=C4)F)F)F,Inactive,IC50,11400
118159387,CC(C)NC1=NC2=C(CCN(C2)C=O)N=C1N3CCC(CC3)[C@@H](C4=C(C=C(C=C4)F)F)F,Inactive,IC50,11400
118159126,CC(C)NC1=NC2=C(CCN(C2)C=O)N=C1N3CCC(CC3)[C@H](C4=C(C=C(C=C4)F)F)F,Inactive,IC50,23600
118159126,CC(C)NC1=NC2=C(CCN(C2)C=O)N=C1N3CCC(CC3)[C@H](C4=C(C=C(C=C4)F)F)F,Inactive,IC50,23600
118159314,CC(C)NC1=NC2=C(CCN(C2)CCF)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,74800
118159314,CC(C)NC1=NC2=C(CCN(C2)CCF)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,74800
118159371,CC(C)NC1=NC2=C(CCN(C2)S(=O)(=O)C(C)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,149000
118159371,CC(C)NC1=NC2=C(CCN(C2)S(=O)(=O)C(C)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,149000
118159255,CC(C)NC1=NC2=C(CCN(C2)S(=O)(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,61800
118159255,CC(C)NC1=NC2=C(CCN(C2)S(=O)(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,61800
118159178,CC(C)NC1=NC2=C(CCN(C2)S(=O)(=O)C)N=C1N3CCN(CC3)CC4=C(C=C(C=C4)F)F,Inactive,IC50,27900
118159178,CC(C)NC1=NC2=C(CCN(C2)S(=O)(=O)C)N=C1N3CCN(CC3)CC4=C(C=C(C=C4)F)F,Inactive,IC50,27900
118159386,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)C#N)F,Inactive,IC50,105000
118159386,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)C#N)F,Inactive,IC50,105000
118159235,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,73700
118159235,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,73700
118159169,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F,Inactive,IC50,62500
118159234,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)S(=O)(=O)C4=C(C=C(C=C4)OC)F,Inactive,IC50,200200
118159234,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)S(=O)(=O)C4=C(C=C(C=C4)OC)F,Inactive,IC50,200200
118159373,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)S(=O)(=O)C4=CC=C(C=C4)F,Inactive,IC50,187700
118159373,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)S(=O)(=O)C4=CC=C(C=C4)F,Inactive,IC50,187700
118159384,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)S(=O)(=O)C4=CC=CC(=C4)F,Inactive,IC50,249800
118159384,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)S(=O)(=O)C4=CC=CC(=C4)F,Inactive,IC50,249800
118159155,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)S(=O)(=O)C4=CC=CC(=C4)OC,Inactive,IC50,341500
118159155,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)S(=O)(=O)C4=CC=CC(=C4)OC,Inactive,IC50,341500
118159336,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)S(=O)(=O)C4=CC=CC=C4F,Inactive,IC50,247000
118159336,CC(C)NC1=NC2=C(CN(CC2)C(=O)C)N=C1N3CCC(CC3)S(=O)(=O)C4=CC=CC=C4F,Inactive,IC50,247000
118159302,CC(C)NC1=NC2=C(CN(CC2)C(=O)C3CC3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)C#N)F,Inactive,IC50,122000
118159302,CC(C)NC1=NC2=C(CN(CC2)C(=O)C3CC3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)C#N)F,Inactive,IC50,122000
118159331,CC(C)NC1=NC2=C(CN(CC2)C(=O)C3CC3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,210600
118159331,CC(C)NC1=NC2=C(CN(CC2)C(=O)C3CC3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,210600
118159203,CC(C)NC1=NC2=C(CN(CC2)C(=O)C3CCCO3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,19500
118159203,CC(C)NC1=NC2=C(CN(CC2)C(=O)C3CCCO3)N=C1N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,19500
118159337,CC(C)NC1=NC2=C(CN(CC2)C(=O)CC#N)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,18000
118159337,CC(C)NC1=NC2=C(CN(CC2)C(=O)CC#N)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,18000
118159392,CC(C)NC1=NC2=C(CN(CC2)C(=O)COC)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,17300
118159392,CC(C)NC1=NC2=C(CN(CC2)C(=O)COC)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,17300
118159180,CC(C)NC1=NC2=C(CN(CC2)C(=O)N(C)C)N=C1N3CCC(CC3)C(=O)C4=C(C=CC(=C4)Cl)F,Inactive,IC50,24900
118159180,CC(C)NC1=NC2=C(CN(CC2)C(=O)N(C)C)N=C1N3CCC(CC3)C(=O)C4=C(C=CC(=C4)Cl)F,Inactive,IC50,24900
118159294,CC(C)NC1=NC2=C(CN(CC2)C(=O)N(C)C)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F,Inactive,IC50,23700
118159294,CC(C)NC1=NC2=C(CN(CC2)C(=O)N(C)C)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F,Inactive,IC50,23700
118159332,CC(C)NC1=NC2=C(CN(CC2)C(=O)N(C)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,13800
118159332,CC(C)NC1=NC2=C(CN(CC2)C(=O)N(C)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,13800
118159196,CC(C)NC1=NC2=C(CN(CC2)C(=O)N(C)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F,Inactive,IC50,16600
118159196,CC(C)NC1=NC2=C(CN(CC2)C(=O)N(C)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F,Inactive,IC50,16600
118159221,CC(C)NC1=NC2=C(CN(CC2)C(=O)NCCOC)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,14900
118159221,CC(C)NC1=NC2=C(CN(CC2)C(=O)NCCOC)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,14900
118159218,CC(C)NC1=NC2=C(CN(CC2)C(=O)OC)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,131700
118159218,CC(C)NC1=NC2=C(CN(CC2)C(=O)OC)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,131700
118159372,CC(C)NC1=NC2=C(CN(CC2)C)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F,Inactive,IC50,17100
118159372,CC(C)NC1=NC2=C(CN(CC2)C)N=C1N3CCC(CC3)C(C4=C(C=C(C=C4)F)F)F,Inactive,IC50,17100
118159352,CC(C)NC1=NC2=C(CN(CC2)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,59500
118159352,CC(C)NC1=NC2=C(CN(CC2)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,59500
118159341,CC(C)NC1=NC2=C(CN(CC2)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F,Inactive,IC50,26600
118159341,CC(C)NC1=NC2=C(CN(CC2)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)OC)F,Inactive,IC50,26600
118159313,CC(C)NC1=NC2=C(CN(CC2)C=O)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,43200
118159313,CC(C)NC1=NC2=C(CN(CC2)C=O)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,43200
118159142,CC(C)NC1=NC2=C(CN(CC2)CC(F)F)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,199700
118159142,CC(C)NC1=NC2=C(CN(CC2)CC(F)F)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,199700
118159173,CC(C)NC1=NC2=C(CN(CC2)CCF)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,69200
118159173,CC(C)NC1=NC2=C(CN(CC2)CCF)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,69200
118159315,CC(C)NC1=NC2=C(CN(CC2)S(=O)(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,95600
118159315,CC(C)NC1=NC2=C(CN(CC2)S(=O)(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,95600
118159199,CC[C@@H](C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,319300
118159199,CC[C@@H](C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,319300
118159206,CC[C@H](C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,62000
118159206,CC[C@H](C)NC1=NC2=C(CCN(C2)C(=O)C)N=C1N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,62000
118180375,CC1C2=C(CCN1C(=O)C(F)F)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC(C)C,Inactive,IC50,115500
118180375,CC1C2=C(CCN1C(=O)C(F)F)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC(C)C,Inactive,IC50,115500
118159363,CC1C2=C(CCN1C(=O)C(F)F)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F,Inactive,IC50,193300
118159363,CC1C2=C(CCN1C(=O)C(F)F)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F,Inactive,IC50,193300
118159325,CC1C2=C(CCN1C(=O)C(F)F)N=C(C(=N2)NC(C)C)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,95000
118159325,CC1C2=C(CCN1C(=O)C(F)F)N=C(C(=N2)NC(C)C)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,95000
118159298,CC1C2=C(CCN1C(=O)C(F)F)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,212200
118159298,CC1C2=C(CCN1C(=O)C(F)F)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,212200
118159163,CC1C2=C(CCN1C(=O)C)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC(C)C,Inactive,IC50,88000
118159163,CC1C2=C(CCN1C(=O)C)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC(C)C,Inactive,IC50,88000
118159172,CC1C2=C(CCN1C(=O)C)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F,Inactive,IC50,76000
118159172,CC1C2=C(CCN1C(=O)C)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F,Inactive,IC50,76000
118857196,CC1C2=C(CCN1C(=O)C)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)OC)F)NC(C)C,Inactive,IC50,62500
118159253,CC1C2=C(CCN1C(=O)C)N=C(C(=N2)NC(C)C)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,73200
118159253,CC1C2=C(CCN1C(=O)C)N=C(C(=N2)NC(C)C)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,73200
118159119,CC1C2=C(CCN1C(=O)C)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,178000
118159119,CC1C2=C(CCN1C(=O)C)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,178000
118159258,CC1C2=C(CCN1C(=O)C3CC3)N=C(C(=N2)N4CCC(CC4)OC5=C(C=C(C=C5)F)F)NC(C)C,Inactive,IC50,259000
118159258,CC1C2=C(CCN1C(=O)C3CC3)N=C(C(=N2)N4CCC(CC4)OC5=C(C=C(C=C5)F)F)NC(C)C,Inactive,IC50,259000
118159338,CC1C2=C(CCN1C(=O)C3CC3)N=C(C(=N2)N4CCC(CC4)OC5=C(C=C(C=C5)F)F)NCC(F)F,Inactive,IC50,126000
118159338,CC1C2=C(CCN1C(=O)C3CC3)N=C(C(=N2)N4CCC(CC4)OC5=C(C=C(C=C5)F)F)NCC(F)F,Inactive,IC50,126000
118159310,CC1C2=C(CCN1C(=O)C3CC3)N=C(C(=N2)NCC(F)F)N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,85000
118159310,CC1C2=C(CCN1C(=O)C3CC3)N=C(C(=N2)NCC(F)F)N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,85000
118159181,CC1C2=C(CCN1C(=O)COC)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC(C)C,Inactive,IC50,91000
118159181,CC1C2=C(CCN1C(=O)COC)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC(C)C,Inactive,IC50,91000
118159227,CC1C2=C(CCN1C(=O)COC)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F,Inactive,IC50,68000
118159227,CC1C2=C(CCN1C(=O)COC)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F,Inactive,IC50,68000
118159333,CC1C2=C(CCN1C(=O)COC)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,208000
118159333,CC1C2=C(CCN1C(=O)COC)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,208000
118159380,CC1C2=C(CCN1C(=O)N(C)C)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC(C)C,Inactive,IC50,179400
118159380,CC1C2=C(CCN1C(=O)N(C)C)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC(C)C,Inactive,IC50,179400
118159122,CC1C2=C(CCN1C(=O)N(C)C)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F,Inactive,IC50,93500
118159122,CC1C2=C(CCN1C(=O)N(C)C)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F,Inactive,IC50,93500
118159383,CC1C2=C(CCN1C(=O)N(C)C)N=C(C(=N2)NC(C)C)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,109600
118159383,CC1C2=C(CCN1C(=O)N(C)C)N=C(C(=N2)NC(C)C)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,109600
118159345,CC1C2=C(CCN1S(=O)(=O)C)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC(C)C,Inactive,IC50,98000
118159345,CC1C2=C(CCN1S(=O)(=O)C)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC(C)C,Inactive,IC50,98000
118159342,CC1C2=C(CCN1S(=O)(=O)C)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F,Inactive,IC50,52000
118159342,CC1C2=C(CCN1S(=O)(=O)C)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F,Inactive,IC50,52000
118159355,CC1C2=C(CCN1S(=O)(=O)C)N=C(C(=N2)NC(C)C)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,59300
118159355,CC1C2=C(CCN1S(=O)(=O)C)N=C(C(=N2)NC(C)C)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,59300
118159299,CC1C2=C(CCN1S(=O)(=O)C)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,87000
118159299,CC1C2=C(CCN1S(=O)(=O)C)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,87000
118159308,CC1CC2=C(CN1C(=O)[C@@H](C)OC)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,18500
118159308,CC1CC2=C(CN1C(=O)[C@@H](C)OC)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,18500
118159270,CC1CC2=C(CN1C(=O)[C@H](C)OC)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,20900
118159270,CC1CC2=C(CN1C(=O)[C@H](C)OC)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,20900
118159241,CC1CC2=C(CN1C(=O)C(F)F)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,22100
118159241,CC1CC2=C(CN1C(=O)C(F)F)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,22100
118159131,CC1CC2=C(CN1C(=O)C)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,24900
118159131,CC1CC2=C(CN1C(=O)C)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,24900
118159159,CC1CC2=C(CN1C(=O)C3CC3)N=C(C(=N2)NCC(F)F)N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,23900
118159159,CC1CC2=C(CN1C(=O)C3CC3)N=C(C(=N2)NCC(F)F)N4CCC(CC4)OC5=C(C=C(C=C5)F)F,Inactive,IC50,23900
118159295,CC1CC2=C(CN1C(=O)COC)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,23000
118159295,CC1CC2=C(CN1C(=O)COC)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,23000
118159260,CC1CC2=C(CN1C(=O)N(C)C)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,31400
118159260,CC1CC2=C(CN1C(=O)N(C)C)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,31400
118159391,CC1CC2=C(CN1C)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,23200
118159391,CC1CC2=C(CN1C)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,23200
118159264,CC1CC2=C(CN1S(=O)(=O)C)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,10400
118159264,CC1CC2=C(CN1S(=O)(=O)C)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,10400
118159189,CCC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)N[C@H]5CCOC5,Inactive,IC50,39200
118159189,CCC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)N[C@H]5CCOC5,Inactive,IC50,39200
118159148,CCC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC(C)C,Inactive,IC50,27600
118159148,CCC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC(C)C,Inactive,IC50,27600
118159364,CCC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)N[C@H]5CCOC5,Inactive,IC50,59100
118159364,CCC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)N[C@H]5CCOC5,Inactive,IC50,59100
118159125,CCC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)NC(C)C,Inactive,IC50,30900
118159125,CCC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCN(CC3)CC4=C(C=C(C=C4)F)F)NC(C)C,Inactive,IC50,30900
118159322,CN(C)C(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F,Inactive,IC50,26900
118159322,CN(C)C(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F,Inactive,IC50,26900
118159324,CN(C)C(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)OC)F)NC5CCC5,Inactive,IC50,32500
118159324,CN(C)C(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)OC)F)NC5CCC5,Inactive,IC50,32500
118159378,CN(C)C(=O)N1CCC2=C(C1)N=C(C(=N2)NC3CCC3)N4CCC(CC4)OC5=C(C=C(C=C5)OC)F,Inactive,IC50,13800
118159378,CN(C)C(=O)N1CCC2=C(C1)N=C(C(=N2)NC3CCC3)N4CCC(CC4)OC5=C(C=C(C=C5)OC)F,Inactive,IC50,13800
118159243,CN1CCC2=C(C1)N=C(C(=N2)NC3CC3)N4CCC(CC4)[C@@H](C5=C(C=C(C=C5)F)F)F,Inactive,IC50,15200
118159243,CN1CCC2=C(C1)N=C(C(=N2)NC3CC3)N4CCC(CC4)[C@@H](C5=C(C=C(C=C5)F)F)F,Inactive,IC50,15200
118159251,CN1CCC2=C(C1)N=C(C(=N2)NC3CC3)N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F,Inactive,IC50,26500
118159251,CN1CCC2=C(C1)N=C(C(=N2)NC3CC3)N4CCC(CC4)[C@H](C5=C(C=C(C=C5)F)F)F,Inactive,IC50,26500
118159306,CN1CCC2=C(C1)N=C(C(=N2)NC3CC3)N4CCC(CC4)OC5=C(C=C(C=C5)OC)F,Inactive,IC50,145000
118159306,CN1CCC2=C(C1)N=C(C(=N2)NC3CC3)N4CCC(CC4)OC5=C(C=C(C=C5)OC)F,Inactive,IC50,145000
118159408,COCC(=O)N1CCC2=C(C1)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,79500
118159408,COCC(=O)N1CCC2=C(C1)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,79500
118159205,CS(=O)(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CCC5,Inactive,IC50,49300
118159205,CS(=O)(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CCC5,Inactive,IC50,49300
118180378,CS(=O)(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F,Inactive,IC50,57200
118180378,CS(=O)(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NCC(F)F,Inactive,IC50,57200
118159305,CS(=O)(=O)N1CCC2=C(C1)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,163000
118159305,CS(=O)(=O)N1CCC2=C(C1)N=C(C(=N2)NCC(F)F)N3CCC(CC3)OC4=C(C=C(C=C4)F)F,Inactive,IC50,163000