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<!DOCTYPE html>
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<title>The Nesvizhskii Lab</title>
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<h2>Proteomics Resource Facility</h2>
<h4>4556 MSRB II</h4>
<br>
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The mass spectrometry-based Proteomics Resource Facility (PRF)
at the Department of Pathology began operating in 2007.
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<img alt="Proteomics Resource Facility" src="img/prf-2019.jpg">
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<br>
<p>
The goal of the PRF is to assist researchers in designing
proteomic experiment, maintain state-of-the-art instrumentation,
provide technical expertise and bioinformatic support during
both discovery and validation phases of proteomic experiments.
During the discovery phase, services offered by the PRF
include identification of proteins from multiple sources
(such as Coomassie and silver-stained gels), identification of
post-translational modifications, and shotgun proteomic
analysis of complex mixtures using either one- or
two-dimensional liquid chromatography.
Relative quantification (differential proteomic analysis)
using stable isotope labeling of amino acids in culture
(SILAC), isotope-coded affinity tags (e.g. TMT) and label-free
analyses are also offered.
</p>
<p>
For validation of findings from the discovery phase
(especially projects related to biomarker discovery),
a researcher may wish to employ a more targeted approach and
expand the sample size. The PRF provides support for relative
and absolute quantification (AQUA) of multiple analytes using
Parallel Reaction Monitoring (PRM).
</p>
<p>
The PRF is equipped with two Thermo Scientific mass
spectrometers devoted exclusively for proteomic analysis.
These include:
</p>
<p>1. Orbitrap Fusion Tribrid with ETD</p>
<p>2. Q Exactive HF</p>
<p>
Both mass spectrometers are equipped with dedicated nano-LC
systems (Dionex RSLC-nano).
</p>
</br>
<p>To learn more and submit samples,
please visit the <a href="https://www.pathology.med.umich.edu/proteomics-resource-facility">Proteomics Resource Facility website</a>.
</p>
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<p class="sub">Department of Pathology. University of Michigan Medical School.</p>
<ul>
<li>nesvi@umich.edu<br>+1 734.764.3516<br></li>
<li>Room 1590, MSRB II<br>
1150 West Medical Center Drive<br>
Ann Arbor, MI 48109-0602</li>
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