- Assess how well an SBML is approximated by one or more linear models based on
- Consistency of Jacobian
- Accuracy of reproducing a non-linear simulation
- Identify "linearity bottleneck" reactions, those that must limit the viability of a linear approximation
- Need sufficient data, maybe in the 1000s.
- Reduce threshold (sensitivity) to get more sparse coefficients
- Set includebias = True
- Don't include boundary species