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Splitting fastq files, mapping and then merging them (like bcbio used to do), can provide a significant speedup for alignment.
This needs to be post 1.0 as it's quite an invasive change.
Description of feature
Splitting fastq files, mapping and then merging them (like bcbio used to do), can provide a significant speedup for alignment.
This needs to be post 1.0 as it's quite an invasive change.
The parts that need to be done:
MarkDuplicatesSpark(requires some tweaks to sorting, or it gets insanely slow)